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Accessing genetically defined cell types in the Superior Colliculus with transgenic mouse lines

ABSTRACT: Accessing genetically defined cell types in the Superior Colliculus with transgenic mouse lines

PROVIDER: PRJNA1214831 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR32096980.fastq.gz	Fastqsanger.gz
	SRR32096981.fastq.gz	Fastqsanger.gz
	SRR32096982.fastq.gz	Fastqsanger.gz
	SRR32096983.fastq.gz	Fastqsanger.gz
	SRR32096984.fastq.gz	Fastqsanger.gz

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Accessing genetically defined cell types in the Superior Colliculus with transgenic mouse lines

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Effects of eye opening on gene expression in the superficial layers of the rat superior colliculus

Project description:We performed RNA-seq on six samples of P20 Sprague Dawley rat superior colliculus, three control rats that underwent eye opening at P14 until P20 and three deprived rats which had their eyes glued closed from P14 until P20. Each sample was created from two pooled colliculi. RNA-seq of the superior colliculus with and without long term light deprivation.

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Modular organization of the motor space in the mouse superior colliculus

Project description:In order to characterize the genetic diversity within the Stratum Griseum Intermediale (SGI), we screened gene expression by extracting RNA from sensory and motor layers of the Superior Colliculus (SC) at post-natal day (P)7.

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Mapping Visual Functions onto Molecular Cell Types in the Mouse Superior Colliculus

Project description:To facilitate investigation of function, connectivity, and development of superficial superior colliculus (sSC), we identified 28 neuron subtypes and subtype-enriched marker genes from tens of thousands of adult mouse sSC neurons

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Multipotent Progenitors Instruct Ontogeny of the Superior Colliculus

Project description:Multipotent Progenitors Instruct Ontogeny of the Superior Colliculus

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Multipotent Progenitors Instruct Ontogeny of the Superior Colliculus – Pten

Project description:Multipotent Progenitors Instruct Ontogeny of the Superior Colliculus – Pten

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Effects of eye opening on gene expression in the superficial layers of the rat superior colliculus

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Chronic chemogenetic activation of the superior colliculus in glaucomatous mice: local and retrograde molecular signature

Project description:One important facet of the glaucoma pathology is axonal damage, which ultimately disrupts the connection between the retina and its postsynaptic targets. The concurrent loss of retrograde support interferes with the functionality and survival of the retinal ganglion cells (RGCs). Con-versely, previous research has shown that stimulation of neuronal activity in a primary retinal target area—i.e., the superior colliculus— promotes RGC survival in an acute mouse model of glaucoma. To build further on this observation, we applied repeated chemogenetics in the superior colliculus of a more chronic model of glaucoma—i.e., the microbead occlusion model—and per-formed bulk RNA sequencing on collicular lysates and isolated RGCs. Our study revealed that chronic target stimulation upon glaucomatous injury phenocopies the a priori expected molecular response: growth factors were pinpointed as essential transcriptional regulators both in the locally stimulated tissue and in distant, unstimulated RGCs. Strikingly, and although the RGC tran-scriptome revealed an enrichment of pro-survival signaling pathways, functional rescue of injured RGCs was not achieved.

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Genetically Defined Functional Modules for Spatial Orienting in the Mouse Superior Colliculus.

Project description:In order to explore and interact with their surroundings, animals need to orient toward specific positions in space. Throughout the animal kingdom, head movements represent a primary form of orienting behavior. The superior colliculus (SC) is a fundamental structure for the generation of orienting responses, but how genetically distinct groups of collicular neurons contribute to these spatially tuned behaviors remains largely to be defined. Here, through the genetic dissection of the murine SC, we identify a functionally and genetically homogeneous subclass of glutamatergic neurons defined by the expression of the paired-like homeodomain transcription factor Pitx2. We show that the optogenetic stimulation of Pitx2ON neurons drives three-dimensional head displacements characterized by stepwise, saccade-like kinematics. Furthermore, during naturalistic foraging behavior, the activity of Pitx2ON neurons precedes and predicts the onset of spatially tuned head movements. Intriguingly, we reveal that Pitx2ON neurons are clustered in an orderly array of anatomical modules that tile the entire intermediate layer of the SC. Such a modular organization gives origin to a discrete and discontinuous representation of the motor space, with each Pitx2ON module subtending a defined portion of the animal's egocentric space. The modularity of Pitx2ON neurons provides an anatomical substrate for the convergence of spatially coherent sensory and motor signals of cortical and subcortical origins, thereby promoting the recruitment of appropriate movement vectors. Overall, these data support the view of the superior colliculus as a selectively addressable and modularly organized spatial-motor register.

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