Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

RNA-sequencing of gastric tissues derived from five inflamed-type and five desert-type tumors

ABSTRACT: RNA-sequencing of gastric tissues derived from five inflamed-type and five desert-type tumors

PROVIDER: PRJNA1220931 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR32269626_1.fastq.gz	Fastqsanger.gz
	SRR32269626_2.fastq.gz	Fastqsanger.gz
	SRR32269627_1.fastq.gz	Fastqsanger.gz
	SRR32269627_2.fastq.gz	Fastqsanger.gz
	SRR32269628_1.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 20

Similar Datasets

scRNA-sequencing of gastric tissues derived from eight inflamed-type and eight desert-type tumors

Project description:This study reports single-cell RNA sequencing (scRNA-seq) data from 16 human gastric cancer tumor samples. The cohort includes 8 immune-inflamed-type and 8 immune-desert-type tumors, aiming to characterize the cellular and transcriptomic landscapes associated with distinct immune phenotypes in gastric cancer. The dataset provides high-resolution profiles of tumor and immune cell states, enabling the investigation of epithelial-intrinsic regulators and cell-type-specific programs regulating immune desertification.

2026-07-31 | GSE341101 | GEO

RNA-sequencing of gastric tissues derived from five inflamed-type and five desert-type tumors

Project description:Transforming gastric tumors from immunosuppressive to immunostimulatory is a potential approach to enhance immune checkpoint blockade response. Here, we developed a chromosomal instability subtype gastric cancer mouse model with an immunoactive tumor microenvironment (TME) and a stem cell-originated mouse-derived allograft model with an immunosuppressed TME to investigate mechanisms regulating the tumor immunophenotype and uncover therapeutic strategies to remodel the TME.

2025-02-18 | GSE289066 | GEO

scRNA-sequencing of gastric tissues derived from eight inflamed-type and eight desert-type tumors

Project description:scRNA-sequencing of gastric tissues derived from eight inflamed-type and eight desert-type tumors

| PRJNA1499457 | ENA

scRNA-sequencing of gastric tissues derived from three inflamed-type and three desert-type tumors

Project description:scRNA-sequencing of gastric tissues derived from three inflamed-type and three desert-type tumors

| PRJNA1221573 | ENA

scRNA-sequencing of gastric tissues derived from three inflamed-type and three desert-type tumors

2025-02-18 | GSE289116 | GEO

DDX54 downregulation enhances anti-PD1 therapy in immune-desert lung tumors with high tumor mutational burden

Project description:High tumor mutational burden (TMB) is a predictive biomarker for the responsiveness of cancer to immune checkpoint inhibitor therapy that indicates whether immune cells can sufficiently recognize cancer cells as non-self. However, about 30% of all cancers from The Cancer Genome Atlas are classified as immune-desert tumors lacking T cell infiltration despite high TMB. Since the underlying mechanism of these immune-desert tumors has yet to be unraveled, there is a pressing need to transform such immune-desert tumors into immune-inflamed tumors and thereby enhance their responsiveness to anti-PD1 therapy. Here, we present a systems framework for identifying immuno-oncotargets, based on analysis of gene regulatory networks, and validating the effect of these targets in transforming immune-desert into immune-inflamed tumors. In particular, we identify DEAD-box helicases 54 (DDX54) as a master regulator of immune escape in immune-desert lung cancer with high TMB, and show that knockdown of DDX54 can increase immune cell infiltration and lead to improved sensitivity to anti-PD1 therapy.

2025-03-19 | GSE268555 | GEO

DDX54 downregulation enhances anti-PD1 therapy in immune-desert lung tumors with high tumor mutational burden

2025-03-19 | GSE289119 | GEO

DDX54 downregulation enhances anti-PD1 therapy in immune-desert lung tumors with high tumor mutational burden

2025-03-19 | GSE285342 | GEO

DDX54 downregulation enhances anti-PD1 therapy in immune-desert lung tumors with high tumor mutational burden

2025-03-19 | GSE285341 | GEO

Spatial transcriptomic profiling of human gastric cancer FFPE specimens

Project description:Spatial transcriptomics mapped in-situ immune cell distribution and gene expression of FFPE gastric cancer, spatially confirming RASAL2 enrichment in immune-desert tumor regions and linking intratumoral heterogeneity to immune exclusion.

2026-07-31 | GSE338506 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data