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Transcription factor ELF-1 protects against colitis by maintaining intestinal epithelium homeostasis

ABSTRACT: Transcription factor ELF-1 protects against colitis by maintaining intestinal epithelium homeostasis

PROVIDER: PRJNA1221877 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR32296386_1.fastq.gz	Fastqsanger.gz
	SRR32296386_2.fastq.gz	Fastqsanger.gz
	SRR32296387_1.fastq.gz	Fastqsanger.gz
	SRR32296387_2.fastq.gz	Fastqsanger.gz
	SRR32296388_1.fastq.gz	Fastqsanger.gz

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Transcription factor ELF-1 protects against colitis by maintaining intestinal epithelium homeostasis

Project description:Inflammatory bowel disease (IBD) is a chronic, relapsing, and remitting disease characterized by chronic inflammation in the gastrointestinal tract. The exact etiology and pathogenesis of IBD remain elusive. Although ELF-1 has been known to be highly expressed in epithelial cells for past twenty years, little is known about its function in epithelial cells and epithelial-related IBD. Here, we demonstrated that ELF-1 deficiency in mouse lead to exacerbated DSS-induced colitis, marked by inflammation dominated by neutrophil infiltration and activation of IL-17 signaling pathways in various immune cells, including Th17, ILC3, γδT and NKT cells. Bone marrow transfer experiments confirmed ELF-1 deficiency in non-hematopoietic cells intrinsically worsened DSS-induced colitis. On one hand, ELF-1 deficiency enhanced the production of pro-inflammatory chemokines in colonic epithelial cells, leading to extensive infiltration of neutrophils and other immune cells into the colonic mucosal tissue. On the other hand, ELF-1 directly regulated the expression of the Rack1 gene in colonic epithelial tissue, which has been proved to play critical roles in maintaining intestinal homeostasis. Altogether, ELF-1 plays a protective role in colitis by maintaining intestinal epithelium homeostasis.

2025-02-12 | GSE289183 | GEO

Transcription factor ELF-1 protects against colitis by maintaining intestinal epithelium homeostasis.

| S-EPMC11890729 | biostudies-literature

The effects of ELF-1 on gene expression profiles of colonic tissue in DSS colitis at single cell level

Project description:The maintenance of intestinal homeostasis is closely related to the epithelial integrity and permeability.Elf-1 has been shown to play an important role in the development and maintenance of various hematopoietic lineages,as well as in the regulating the function of endothelial cells during tumor angiogenesis.Here, we characterized the intestinal cell landscape in DSS-induced model with Elf-1 deficiency at the single-cell level, and uncovered the disruption of intestinal immune homeostasis associated with Elf-1 deficiency.

2025-02-12 | GSE269385 | GEO

Tetraspanin CD151 protects against pulmonary fibrosis by maintaining epithelial integrity

Project description:Tetraspanin CD151 protects against pulmonary fibrosis by maintaining epithelial integrity

| PRJNA668118 | ENA

Function of Epithelium BRG1 in colitis and CAC

Project description:Function of Epithelium BRG1 in colitis and CAC

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cDNA microarray analysis of human keratinocytes irradiated by ELF-EMF

Project description:The ami of this study was to investigate the possible biological effects of ELF-EMF by cDNA microarray. Keywords: ELF-EMF, cDNA microarray, keratinocyte, cytoskeleton

2006-10-12 | GSE3421 | GEO

Expression profiling analysis ELF-deficient and ELF-expressing human bile duct cells

Project description:Expression profiling analysis ELF-deficient and ELF-expressing human bile duct cells

| PRJNA623266 | ENA

MicroRNA expression proﬁling in GC-2 cells following 50 Hz ELF-EMF

Project description:Aberrant miRNA expression has been related to the development of human germ cell tumors, but little is known about effect of ELF-EMFs on miRNA expression. ELF-EMFs may epigenetically modify cells, which may account for the adverse effects of ELF-EMFs on the male reproductive system. To identify miRNAs that were differentially expressed between the sham and ELF-EMF exposure groups, we performed an Affymetrix microarray analysis to establish the miRNA expression profiles.

2016-07-01 | GSE71147 | GEO

Study of extremely low frequency electromagnetic field (ELF-EMF) responses of human HaCaT keratinocytes: Control vs. ELF-EMF

Project description:Use DNA microarray technology to discover transciprtional insights of HaCaT for continuous exposure to ELF-EMF We used a loop design in this study (details in the 'loop_design.tiff' supplementary file), cDNA microarray experiment consisted of ten RNA samples, including ELF-EMF exposed, UVB irradiated (positive control), and sham exposed samples.

2014-03-29 | E-GEOD-45631 | biostudies-arrayexpress

Expression data from colon epithelium of STAT3IEC-KO in acute DSS colitis

Project description:STAT3 is a pleiotropic transcription factor with important functions in cytokine signalling in a variety of tissues. However, the role of STAT3 in the intestinal epithelium is not well understood. Here we demonstrate that development of colonic inflammation is associated with the induction of STAT3 activity in intestinal epithelial cells (IEC). Studies in genetically engineered mice showed that epithelial STAT3 activation in DSS colitis is dependent on IL-22 rather than IL-6. IL-22 was secreted by colonic CD11c+ cells in response to Toll-like receptor stimulation. Conditional knockout mice with an IEC specific deletion of STAT3 activity were highly susceptible to experimental colitis, indicating that epithelial STAT3 regulates gut homeostasis. STAT3IEC-KO mice, upon induction of colitis, showed a striking defect of epithelial restitution. Gene chip analysis indicated that STAT3 regulates the cellular stress response, apoptosis and pathways associated with wound healing in IEC. Consistently, both IL-22 and epithelial STAT3 were found to be important in wound-healing experiments in vivo. In summary, our data suggest that intestinal epithelial STAT3 activation regulates immune homeostasis in the gut by promoting IL-22-dependent mucosal wound healing. 4 samples of colon epithelium were analyzed from 4 mice (2 per group Stat3flfl VillinCre- and Stat3flfl VillinCre+, respectively) after they had been treated with DSS (2.5%) for 5 days

2009-05-08 | E-GEOD-15955 | biostudies-arrayexpress

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