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Bulk RNA-seq of Kupffer cells from Hepa1-6_EV (empty vector) and Hepa1-6_EpoOE (overexpression) HCC-bearing C57BL/6 mice

ABSTRACT: Bulk RNA-seq of Kupffer cells from Hepa1-6_EV (empty vector) and Hepa1-6_EpoOE (overexpression) HCC-bearing C57BL/6 mice

PROVIDER: PRJNA1228958 | ENA |

REPOSITORIES: ENA

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Bulk RNA-seq of Kupffer cells from Hepa1-6_EV (empty vector) and Hepa1-6_EpoOE (overexpression) HCC-bearing C57BL/6 mice

Project description:Successful cancer immunotherapy requires a patient to mount an effective immune response against tumors, however many cancers evade the body’s immune system. To investigate the basis for treatment failure, we examined spontaneous mouse models of hepatocellular carcinoma (HCC) with either an inflamed T-cell-rich or non-inflamed T-cell-deprived tumor microenvironment (TME). Our studies reveal that erythropoietin (EPO) secreted by tumor cells determines tumor immunotype. Tumor-derived EPO autonomously generates a non-inflamed TME by interacting with its cognate receptor EPOR on tumor-associated macrophages (TAMs). EPO signaling prompts TAMs to become immunoregulatory via NRF2-mediated heme depletion. Removing either tumor-derived EPO or EPOR on TAMs leads to an inflamed TME and tumor regression independent of genotype, due to augmented antitumor T-cell immunity. Thus, the EPO/EPOR axis functions as an immunosuppressive switch for anti-tumor immunity.

2025-04-30 | GSE290606 | GEO

miRNA profiling of Hepa1-6-bearing mouse model

Project description:miRNA profiling of Hepa1-6-bearing mouse model

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Transcriptional profiling of Hepa1-6-bearing mouse model

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Transcriptional profiling of Hepa1-6-bearing mouse model

Project description:Hepa1-6-bearing C57BL/6 mouse model was established to evaluate the therapeutic efficacy of Ganoderma lucidum extract (GLE) in HCC. The GLE treated and untreated mice were used for transcriptioanl profiles detection, and 126 differentially expressed lncRNAs and 558 DE mRNAs were identified, respectively. The bioinformatics analysis shows that the GLE could suppress the growth and proliferation of HCC by PI3K/Akt/mTOR and MAPK signaling pathway, and also could induce apoptosis of tumor cell by mitochondrial and death receptor pathway.

2018-08-02 | GSE117503 | GEO

miRNA profiling of Hepa1-6-bearing mouse model

Project description:the Hepa1-6-bearing C57 BL/6 mouse model was utilized to explore the therapeutic efficacy of Ganoderma lucidum extract (GLE), documenting that it could effectively inhibit tumor growth. Furthermore, the microRNA (miRNA) profiles of GLE-treated and untreated mice were detected, and 25 differential expressed (DE) miRNAs were determined, including 24 up-expressed and one down-expressed miRNAs., documenting that it could effectively inhibit tumor growth. Furthermore, the microRNA (miRNA profiles of GLE-treated and untreated mice were detected, and 25 differential expressed (DE miRNAs were determined, including 24 up-expressed and one down-expressed miRNAs.

2019-12-29 | GSE142692 | GEO

Osteopontin vs empty vector

Project description:Osteopontin tranfected vs empty vector breast cell line Keywords: parallel sample

2004-01-07 | GSE939 | GEO

CD133- HCC cells infected with miR-130b vs. empty vector control

Project description:To identify candidate downstream mRNA target for hsa-miR-130b miR-130b or empty vector control was overexpressed in PLC8024 CD133- HCC cells using lentivirus

2010-12-10 | E-GEOD-17386 | biostudies-arrayexpress

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HCT116 cells N-BLR shRNA vs. empty vector control

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