Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

MiRNA profiling of Hepa1-6-bearing mouse model

ABSTRACT: miRNA profiling of Hepa1-6-bearing mouse model

PROVIDER: PRJNA597994 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Similar Datasets

miRNA profiling of Hepa1-6-bearing mouse model

Project description:the Hepa1-6-bearing C57 BL/6 mouse model was utilized to explore the therapeutic efficacy of Ganoderma lucidum extract (GLE), documenting that it could effectively inhibit tumor growth. Furthermore, the microRNA (miRNA) profiles of GLE-treated and untreated mice were detected, and 25 differential expressed (DE) miRNAs were determined, including 24 up-expressed and one down-expressed miRNAs., documenting that it could effectively inhibit tumor growth. Furthermore, the microRNA (miRNA profiles of GLE-treated and untreated mice were detected, and 25 differential expressed (DE miRNAs were determined, including 24 up-expressed and one down-expressed miRNAs.

2019-12-29 | GSE142692 | GEO

Transcriptional profiling of Hepa1-6-bearing mouse model

Project description:Transcriptional profiling of Hepa1-6-bearing mouse model

| PRJNA482340 | ENA

Transcriptional profiling of Hepa1-6-bearing mouse model

Project description:Hepa1-6-bearing C57BL/6 mouse model was established to evaluate the therapeutic efficacy of Ganoderma lucidum extract (GLE) in HCC. The GLE treated and untreated mice were used for transcriptioanl profiles detection, and 126 differentially expressed lncRNAs and 558 DE mRNAs were identified, respectively. The bioinformatics analysis shows that the GLE could suppress the growth and proliferation of HCC by PI3K/Akt/mTOR and MAPK signaling pathway, and also could induce apoptosis of tumor cell by mitochondrial and death receptor pathway.

2018-08-02 | GSE117503 | GEO

Bulk RNA-seq of Kupffer cells from Hepa1-6_EV (empty vector) and Hepa1-6_EpoOE (overexpression) HCC-bearing C57BL/6 mice

Project description:Bulk RNA-seq of Kupffer cells from Hepa1-6_EV (empty vector) and Hepa1-6_EpoOE (overexpression) HCC-bearing C57BL/6 mice

| PRJNA1228958 | ENA

miRNA profiling of pooled serum circulating cell-free miRNA of Tn+ tumor-bearing mice

Project description:To investigate the systemic impact of Tn+ tumor phenotypes, we conducted an analysis of circulating miRNAs in the serum of mice bearing Tn+- 4T1 tumors. The 4T1/Tn+ cell line was generated via CRISPR/Cas9 targeting of Cosmc, and tumors were established orthotopically in BALB/c mice. Tumor-bearing animals were monitored for primary growth and micrometastatic dissemination to the lungs, followed by serum collection at endpoint. Serum samples were pooled according to tumor Tn status (Tn+ or Tn–) for total RNA extraction, including small RNAs. Using the NanoString nCounter Mouse v1.5 miRNA assay, we profiled miRNA expression in three serum pools (two Tn+, one Tn–), followed by normalization and quality control via the nCounter Advanced Analysis Software. Expression values were normalized using geometric means of internal positive and negative controls, and only stable miRNA regions (CV < 15%) were retained for downstream analysis.

2026-06-23 | GSE302365 | GEO

miRNA profiling of pooled serum circulating cell-free miRNA of Tn+ tumor-bearing mice

Project description:miRNA profiling of pooled serum circulating cell-free miRNA of Tn+ tumor-bearing mice

| PRJNA1290258 | ENA

RNA-sequencing (RNA-seq) analysis of liver tissues from WT and AKR1D1KO mice in Hepa1-6-induced HCC model.

Project description:RNA-sequencing (RNA-seq) analysis of liver tissues from WT and AKR1D1KO mice in Hepa1-6-induced HCC model. WT is referred as wild type, KO is referred as Akr1d1-knockout.

2025-10-09 | GSE279123 | GEO

Expression data from syngeneic Hepa1-6 model in C57Bl/6J mice

Project description:Expression data from syngeneic Hepa1-6 model in C57Bl/6J mice

| PRJNA641716 | ENA

Next Generation Sequencing Facilitates Quantitative Analysis of LSEC and Hepa1-6 mono- and co-cultured

Project description:Purpose: investigating paracrine effects of mono- and/or co-cultured LSEC and Hepa1-6 Method: mRNA profiles of mono- and co-cultured LSEC and Hepa1-6 were generated by deep sequencing. Results: The RNA-seq data confirmed that extracellular matrix-encoding genes were up-regulated by co-cultured LSEC with Hepa1-6.

2023-01-31 | GSE202457 | GEO

Gene expression profiles of Hepa1-6 tumors in C57Bl/6 mice

Project description:Chronological change of gene expression profile of Hepa1-6 tumors in C57Bl/6 Two-condition experiment

2012-07-02 | E-GEOD-38981 | biostudies-arrayexpress