Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

ABSTRACT: Genomic diversity of non-typhoidal Salmonella found in patients suffering from gastroenteritis in Norfolk, UK

PROVIDER: PRJNA1230128 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
		Other
	SRR32527900_1.fastq.gz	Fastqsanger.gz
	SRR32528000_1.fastq.gz	Fastqsanger.gz
	SRR32528000_2.fastq.gz	Fastqsanger.gz
	SRR32528100_1.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 469

Similar Datasets

Expression data from bacterial co-infection study in mice

Project description:Non-typhoidal Salmonella serotypes (NTS) cause a self-limited gastroenteritis while pediatric patients with severe Plasmodium falciparum malaria can develop a life threatening bacteremia that is a major source of child mortality in sub-Saharan Africa. We used microarrays to detail genome-scale gene expression profiles underlying gastrointestinal immune responses to bacterial infection in mice

2012-08-01 | GSE30974 | GEO

Expression data from bacterial co-infection study in mice

2012-07-31 | E-GEOD-30974 | biostudies-arrayexpress

Translation landscape of the enteric pathogen Salmonella enterica serova Typhimurium

Project description:Many non-typhoidal serovars of Salmonella such as Salmonella enterica serovar Typhimurium (S. Typhimurium) are the leading cause of food-borne gastroenteritis, resulting in millions of infections each year and sometimes death. Salmonella enterica serovar Typhimurium is the most common non-typhoidal Salmonella strain isolated from patients around the world and is used as a mouse model to study bacterial pathogenesis and host-microbe interactions. Furthermore, S. Typhimurium is an important pathogen in livestock animals including chickens and cattle. S. Typhimurium utilises a multitude of virulence factors to reach and invade host cells and for its intracellular survival. However, little is known about the mechanism of protein synthesis of these virulence factors at the codon level. Here, we performed RNA-seq and ribosome profiling. Ribosome profiling allows the global mapping of translating ribosomes on the transcriptome and therefore provides direct measure of protein synthesis.

2023-04-01 | E-MTAB-8808 | biostudies-arrayexpress

Comparative analysis of Salmonella Typhi, Paratyphi A, Enteritidis and Typhimurium core proteomes

Project description:Salmonella enterica subsp. enterica contains more than 2,600 serovars of which four are of major medical relevance for humans. While the typhoidal serovars (Typhi and Paratyphi A) are human-restricted and cause enteric fever, non-typhoidal Salmonella serovars (Typhimurium and Enteritidis) have a broad host range and predominantly cause gastroenteritis. In this study, we compared the core proteomes of Salmonella Typhi, Paratyphi A, Typhimurium and Enteritidis using contemporary proteomics. Five isolates, covering different geographical origins, and one reference strain per serovar were grown in vitro to the exponential phase. Protein levels of orthologous proteins between serovars were compared and subjected to gene ontology term enrichment and inferred regulatory interactions. Differential expression of the core proteomes of the typhoidal serovars appears mainly related to cell surface components and, for the non-typhoidal serovars, to pathogenicity. Our findings may guide future development of novel diagnostics and vaccines, and understanding of disease progression.

2019-05-13 | PXD011154 | Pride

Project description:Genomic diversity and epidemiological significance of non-typhoidal Salmonella found in retail food collected in Norfolk, United Kingdom

| PRJNA939716 | ENA

Project description:Non typhoidal Salmonella

| PRJNA659872 | ENA

Typhoidal Salmonella Dendritic Cell Survival Mechanism Revealed by Dual RNA sequencing

Project description:Salmonella enterica represent a major disease burden worldwide. While non-typhoidal Salmonella (NTS) serovars trigger self-limiting diarrhoea, leading to occasional secondary bacteraemia, S. enterica serovar Typhi is responsible for potentially life-threatening Typhoid fever. Dendritic cells (DCs) are key professional antigen presenting cells of the human immune system. The ability of pathogenic bacteria to subvert DC functions and prevent T cell recognition contributes to their survival and dissemination within the host. Here, we adapted Dual RNA-sequencing to define how different Salmonella pathovariants remodel their gene expression in tandem with that of infected DCs. We find DCs harness iron handling pathways to defend against invading Salmonellas, which, the human pathogen S. Typhi is able to circumvent. We show that S. Typhi mounts a robust response to host oxidative stress to avoid host iron-mediated defence mechanisms. In parallel, we provide evidence that invasive non-typhoidal Salmonella employs several strategies to impair DC functions and undertake alternative nutrient scavenging strategies to survive in the hostile intracellular environment.

2021-11-17 | GSE161854 | GEO

Project description:Ceftriaxone resistant Non Typhoidal Salmonella

| PRJNA432628 | ENA

Salmonella enterica subsp. enterica

Project description:Non-Typhoidal Salmonella in India

| PRJNA788076 | ENA

Project description:Non-typhoidal Salmonella in India

| PRJEB47524 | ENA