Project description:We established a transcriptome cohort of pediatric acute myeloid leukemia (n=553) with RNA sequencing. This dataset of cord blood CD34+ cells (n=5, indivisual lots) is normal controls to characterize leukemia-specific expression patterns.
Project description:Pregnant women suffering from depression show alterations in different biological systems, but the exact underlying mechanisms are still not clear. We used microarrays to investigate the transcriptomic modulation in conditions such as depression and risk for developing depression during pregnancy.
Project description:The primary objective of this study was to investigate whole blood transcriptomic signatures in older populations and to assess their relationship with peripheral lymphocyte populations. Whole blood gene expression profiles were evaluated in a cohort of aged individuals undergoing open heart surgery. Transcriptomic signatures were assessed between clinical groupings and proportions of lymphocyte populations from flow cytometry analysis.
Project description:Genome wide DNA methylation profiling of 152 umbilical cord blood samples from CCCEH birth cohort. The Illumina Infinium 450k Human DNA methylation Beadchip was used to obtain DNA methylation profiles across approximately 450,000 CpGs in cord blood samples