Project description:We established a transcriptome cohort of pediatric acute myeloid leukemia (n=553) with RNA sequencing. This dataset of cord blood CD34+ cells (n=5, indivisual lots) is normal controls to characterize leukemia-specific expression patterns.
Project description:Pregnant women suffering from depression show alterations in different biological systems, but the exact underlying mechanisms are still not clear. We used microarrays to investigate the transcriptomic modulation in conditions such as depression and risk for developing depression during pregnancy.
Project description:The primary objective of this study was to investigate whole blood transcriptomic signatures in older populations and to assess their relationship with peripheral lymphocyte populations. Whole blood gene expression profiles were evaluated in a cohort of aged individuals undergoing open heart surgery. Transcriptomic signatures were assessed between clinical groupings and proportions of lymphocyte populations from flow cytometry analysis.
Project description:Post-Traumatic Stress Disorder is a mental health condition that may develop after exposure to a traumatic event. The diagnosis of PTSD is based on clinical signs and symptoms; there is increasing evidence that biological markers aid in the diagnosis of PTSD. In a Dutch military cohort, we compared blood-based transcriptomic profiles of individuals susceptible and resilient to developing PTSD symptoms after combat-trauma exposure. Whole blood samples were collected from susceptible (n=20) and resilient (n=20) military personnel deployed to Afghanistan, 6 months after returning from military deployment.