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Role of ATF4 in regulation of kidney gene expressions, signaling pathways and functions [human RCC4]

ABSTRACT: Role of ATF4 in regulation of kidney gene expressions, signaling pathways and functions [human RCC4]

PROVIDER: PRJNA1231461 | ENA |

REPOSITORIES: ENA

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			Action	DRS
		Other
	SRR32566536_1.fastq.gz	Fastqsanger.gz
	SRR32566536_2.fastq.gz	Fastqsanger.gz
	SRR32566538_1.fastq.gz	Fastqsanger.gz
	SRR32566538_2.fastq.gz	Fastqsanger.gz

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Role of ATF4 in regulation of kidney gene expressions, signaling pathways and functions [human RCC4]

Project description:Activating transcription factor 4 (ATF4) is a transcription factor that mediates the response to stress at the cellular, tissue, and organism level. We deleted the gene encoding ATF4 in the kidney proximal tubules of the wild type (WT) and TRACK (TRAnsgenic model of Cancer of the Kidney (TRACK)) mice by using a temporal and cell type-specific approach. We show that ATF4 plays a major role in regulating the transcriptome and proteome, which, in turn, influences the metabolome and kidney functions. ATF4 deletion changed transcripts of some transporters responsible for nutrient uptake and waste excretion. It modulates metabolisms of fatty acid and glucose in the mouse model of ccRCC. It also changes metabolism in RCC4 cells. These data indicate that ATF4 plays an important role in regulation of kidney functions.

2025-06-25 | GSE291048 | GEO

Role of ATF4 in regulation of kidney gene expressions, signaling pathways and functions [mouse]

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Role of ATF4 in regulation of kidney gene expressions, signaling pathways and functions

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Role of ATF4 in regulation of kidney gene expressions, signaling pathways and functions [mouse]

Project description:Role of ATF4 in regulation of kidney gene expressions, signaling pathways and functions [mouse]

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Expression profile of MESH1 and ATF4 silencing RCC4 cells

Project description:MESH1 encodes for Metazoan SpoT Homolog 1, which is a homologue of bacterial SpoT that mediates bacterial stringent response. In human cells, we found that MESH1-silencing induces an extensive transcriptional response in clear cell carcinoma cell line RCC4 that partially overlap with mammalian cell integrated stress response (ISR), which ATF4 up-regulation is an essential branch of the response. In this study, the goal is to elucidate the role of ATF4 up-regulation in MESH1-silencing transcriptional response.

2021-07-30 | GSE114128 | GEO

Expression profile of MESH1 and ATF4 silencing RCC4 cells

Project description:Expression profile of MESH1 and ATF4 silencing RCC4 cells

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Role of ATF4 in regulation of kidney gene expressions, signaling pathways and functions

Project description:This SuperSeries is composed of the SubSeries listed below.

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Effect of depletion of MIRE on gene expression of RCC4 cells.

Project description:To investigate the effect of depletion of MIRE on gene expression of RCC4 cells. We then performed gene expression profiling analysis using data obtained from RNA-seq.

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Expression profile of RCC4 cells with YAP silencing

Project description:YAP is the one of the effectors of Hippo pathway. YAP promotes organ size growth as well as tumor metastasis. In this study, YAP is silencing in clear cell carcinoma cell line RCC4 to elucidate the downstream targets that promotes the resisntance toward erastin-induced ferroptosis.

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Effect of muscle-specific ATF4 gene knockout (ATF4 mKO) on skeletal muscle mRNA levels in aged mice.

Project description:For additional details see Ebert et al, Identification and Small Molecule Inhibition of an ATF4-dependent Pathway to Age-related Skeletal Muscle Weakness and Atrophy. Quadriceps femoris muscles were harvested from 22-month-old muscle-specfic ATF4 knockout (ATF4 mKO) mice and littermate controls. mRNA levels in ATF4 mKO muscles were normalized to levels in littermate control muscles.

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