RNF25-Mediated NF-κB Activation Drives Anti-Apoptosis and Therapy Resistance in Cancer
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ABSTRACT:
PROVIDER: PRJNA1232002 | ENA |
REPOSITORIES: ENA
Dataset's files
| Action | DRS | |||
|---|---|---|---|---|
| SRR32574226_1.fastq.gz | Fastqsanger.gz | |||
| SRR32574226_2.fastq.gz | Fastqsanger.gz | |||
| SRR32574227_1.fastq.gz | Fastqsanger.gz | |||
| SRR32574227_2.fastq.gz | Fastqsanger.gz | |||
| SRR32574228_1.fastq.gz | Fastqsanger.gz |
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Project description:Dysregulation of the NF-κB pathway is frequently observed in cancers, contributing to therapy resistance by inhibiting apoptosis. In this study, we identify RNF25, an E3 ubiquitin ligase, as a key regulator of signal transduction, inflammation, immune responses, and apoptosis. RNA sequencing (RNA-seq) analysis following RNF25 knockdown revealed significant alterations in key apoptotic regulators and NF-κB signaling components, highlighting the role of RNF25 in apoptotic resistance and therapeutic response. Pathway enrichment analysis further demonstrated disruptions in pro-survival and inflammatory signaling pathways, suggesting that RNF25 knockdown enhances apoptotic sensitivity and may influence treatment efficacy. This dataset provides valuable insights into potential therapeutic targets for overcoming treatment resistance.
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