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Elucidating mechanisms of perfluorobutanoic acid (PFBA) exposure in larval zebrafish (Danio rerio).

ABSTRACT: Elucidating mechanisms of perfluorobutanoic acid (PFBA) exposure in larval zebrafish (Danio rerio).

PROVIDER: PRJNA1232655 | ENA |

REPOSITORIES: ENA

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Elucidating mechanisms of perfluorobutanoic acid (PFBA) exposure in larval zebrafish (Danio rerio).

Project description:Perfluorobutanoic acid (PFBA) is a short-chain polyfluoroalkyl substance (PFAS) that is measurable in fish tissues and environmental matrices. Previous studies suggest that there are adverse effects on animal and human health following exposure to PFBA, however the mechanisms underlying the toxicity are not well characterized. This study measured biological responses (developmental, transcriptome, and behavioral responses) of zebrafish (wild-type AB strain, Danio rerio) following exposure to a range of PFBA concentrations (0.1-100 µl/L). To further elucidate putative mechanisms related to locomotor abnormalities by PFBA, RNA-seq was conducted. These data shed new mechanistic light onto the sublethal effects of lesser studied short chain perfluorinated chemicals.

2025-08-31 | GSE291250 | GEO

Elucidating mechanisms of PFDoDA exposure in larval zebrafish (Danio rerio)

Project description:Elucidating mechanisms of PFDoDA exposure in larval zebrafish (Danio rerio)

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Elucidating mechanisms of PFDoDA exposure in larval zebrafish (Danio rerio)

Project description:Seven day old larval fish were exposed to one of two concentrations of PFDoDA. RNA-seq was conducted on pools of fish

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Mechanism suppressing transcription of the globin genes in Danio rerio nonerythroid cells

Project description:In genomes of modern fish and amphibia α- and β- globin genes are grouped at a single locus that may resemble the ancestral one and is syntenic to α-globin locus of modern warm-blooded vertebrates. In Danio rerio, the major locus of α/β globin genes comprises two subclusters, one of them harboring genes expressed in adult and the other – genes expressed in embryonic and larval erythrocytes. The results of our previous study suggested that the adult subcluster of this locus has evolved into α-globin gene domain of vertebrate animals. Here we studied how adult and embryo-larval genes of Danio rerio major globin gene locus are repressed in fibroblasts. The results obtained suggest that that at least some of the globin genes present within the adult subcluster are repressed by Polycomb similarly to human α-globin genes. Furthermore, within two α/β gene pairs repression of α-type and β-type genes appears to be mediated by different mechanisms as increasing the level of histone acetylation can activate transcription of only β-type genes.

2020-07-17 | GSE154562 | GEO

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Modulation of the zebrafish (Danio rerio) larval microbiota

Project description:Modulation of the zebrafish (Danio rerio) larval microbiota by potential probiotic yeasts

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Sequencing of Danio rerio liver for 2 age groups

Project description:Comparison of Danio rerio liver for 2 age groups treated with Rotenone. The RNA-seq data comprisess two age groups treated with Rotenone. Jena Centre for Systems Biology of Ageing - JenAge (www.jenage.de)

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Sequencing of Danio rerio skin for 3 age groups

Project description:Comparison of temporal gene expression profiles from Danio rerio skin. The RNA-seq data comprise 3 age groups at 5, 24 and 30 months. Jena Centre for Systems Biology of Ageing - JenAge (www.jenage.de)

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Sequencing of Danio rerio skin for 2 age groups

Project description:Comparison of Danio rerio skin for 2 age groups treated with Rotenone. The RNA-seq data comprises two age groups treated with different Rotenone dose levels. Jena Centre for Systems Biology of Ageing - JenAge (www.jenage.de)

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Sequencing of Danio rerio skin for 5 age groups

Project description:Comparison of temporal small RNA gene expression profiles from Danio rerio skin. The smallRNA-seq data comprise 5 age groups at 6, 12, 24, 36 and 42 months. Jena Centre for Systems Biology of Ageing - JenAge (www.jenage.de)

2021-10-19 | GSE117820 | GEO

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