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Prenatal nicotine exposure induces epigenetic alterations in the Notch signaling genes in the proximal colon in rats [MeDIP-seq]

ABSTRACT: Prenatal nicotine exposure induces epigenetic alterations in the Notch signaling genes in the proximal colon in rats [MeDIP-seq]

PROVIDER: PRJNA1236279 | ENA |

REPOSITORIES: ENA

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Prenatal nicotine exposure induces epigenetic alterations in the Notch signaling genes in the proximal colon in rats [MeDIP-seq]

Project description:Background. Prenatal nicotine exposure (PNE) has been shown to significantly impact fetal development, leading to various pathologies in adulthood, including those affecting the digestive system. Despite considerable attention from the scientific community on the health effects of nicotine consumption, the epigenetic effects of nicotine on the colon remain poorly understood. Objective, in this study, we analyzed the epigenetic effects of nicotine on the proximal colon.

2025-07-28 | GSE291981 | GEO

Prenatal nicotine exposure induces epigenetic alterations in the Notch signaling genes in the proximal colon in rats [RNA-seq]

2025-07-28 | GSE291986 | GEO

The prenatal nicotine exposure leads to epigenetic alterations in nervous system signaling genes in the rat [MeDIP]

Project description:Background. Prenatal exposure to nicotine has been documented to impose numerous deleterious effects on fetal development. However, the epigenetic changes promoted by nicotine exposure on germ cell are still not well understood. Objectives. In this study, we focused on elucidating the impact of prenatal nicotine exposure on regulatory epigenetic mechanisms important for the germ cells development. s important for the germ cells development

2024-04-26 | GSE253594 | GEO

Prenatal nicotine exposure induces epigenetic alterations in the Notch signaling genes in the proximal colon in rats [RNA-seq]

Project description:Prenatal nicotine exposure induces epigenetic alterations in the Notch signaling genes in the proximal colon in rats [RNA-seq]

| PRJNA1236281 | ENA

The prenatal nicotine exposure leads to epigenetic alterations in nervous system signaling genes in the rat [RNA-seq]

2024-04-26 | GSE253595 | GEO

Effect of prenatal exposure to nicotine on kidney structure and gene expression in rats

Project description:Here, we investigated whether prenatal exposure to nicotine alters kidney glomerular mass and genome-wide gene expression profiles in two genetically distant strains of rats, namely spontaneously hypertensive rats (SHR) and Brown Norway (BN) rats. Nicotine or saline were administered to BN and SHR dams via osmotic pumps throughout gestation. Kidneys from 9-week-old male offspring were studied. Equal amounts of RNA from individual animals were pooled within each of the four experimental groups SHR (nicotine: n=13; saline: n=12) and BN (nicotine: n=12; saline: n=12) and hybridized with the Rat RAE-230a GeneChip (Affymetrix).

2012-12-25 | E-GEOD-29677 | biostudies-arrayexpress

Effect of prenatal exposure to nicotine on kidney structure and gene expression in rats

2012-12-25 | GSE29677 | GEO

The prenatal nicotine exposure leads to epigenetic alterations in nervous system signaling genes in the rat [MeDIP]

Project description:The prenatal nicotine exposure leads to epigenetic alterations in nervous system signaling genes in the rat [MeDIP]

| PRJNA1066336 | ENA

Nicotine exposure declines quality of early embryos and disrupts placental structure by destabilizing Notch signaling pathway

Project description:Nicotine is a common environmental pollution which is diffused into the air in the form of cigarette smoke fumes. Due to its lipophilic nature, nicotine can rapidly transport through membrane barriers and spread throughout the body which leads to abnormalities in the human brain, heart and even the fatal. However, the effects of nicotine on early embryonic development remains elusive. In this study, we found that nicotine significantly affected early embryonic development with decreased blastocyst formation. In addition, embryos treated with nicotine caused increased level of ROS, DNA damage and cell apoptosis. By RNA sequencing analysis, we demonstrated that nicotine affected the expression of placental development genes. Consistently, we found that the placental development at E17.5 was impaired by nicotine exposure, with increased placental weight and disrupted placental structure. This was due to excessive activation of the Notch signaling pathway, since blocking Notch signal by DAPT treatment recovered abnormal placental weight and structure induced by nicotine exposure. We also observed that nicotine exposure could specifically cause promoter hypermethylation of Phlda2 (a maternally expressed imprinted gene associated with placental development) and lead to its abnormal expression. Overall, this study provides evidence that nicotine causes the declining quality of early embryo and leads to placental abnormalities related with over-activation of the Notch signaling pathway.

2023-10-17 | GSE186660 | GEO

Gestational food-restriction but not nicotine exposure regulates gene expression in the striatum of adolescent rats

Project description:We used microarrays to determine the effect of prenatal nicotine exposure on gene expression profiles in the striatum of adolescent rats. We found a number of immediate early genes to be differentially expressed due to food-restriction. We compared control (n=8), nicotine exposed (n=7) and a group of animals matched to the food intake of nicotine exposed animals (n=10) to identify gene expression changes associated with prenatal nicotine exposure

2013-09-06 | E-GEOD-50607 | biostudies-arrayexpress

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