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Prenatal nicotine exposure induces epigenetic alterations in the Notch signaling genes in the proximal colon in rats [RNA-seq]

ABSTRACT: Prenatal nicotine exposure induces epigenetic alterations in the Notch signaling genes in the proximal colon in rats [RNA-seq]

PROVIDER: PRJNA1236281 | ENA |

REPOSITORIES: ENA

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Prenatal nicotine exposure induces epigenetic alterations in the Notch signaling genes in the proximal colon in rats [RNA-seq]

Project description:Background. Prenatal nicotine exposure (PNE) has been shown to significantly impact fetal development, leading to various pathologies in adulthood, including those affecting the digestive system. Despite considerable attention from the scientific community on the health effects of nicotine consumption, the epigenetic effects of nicotine on the colon remain poorly understood. Objective, in this study, we analyzed the epigenetic effects of nicotine on the proximal colon.

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Prenatal nicotine exposure induces epigenetic alterations in the Notch signaling genes in the proximal colon in rats [MeDIP-seq]

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Project description:We used microarrays to determine the effect of prenatal nicotine exposure on gene expression profiles in the striatum of adolescent rats. We found a number of immediate early genes to be differentially expressed due to food-restriction. We compared control (n=8), nicotine exposed (n=7) and a group of animals matched to the food intake of nicotine exposed animals (n=10) to identify gene expression changes associated with prenatal nicotine exposure

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Nicotine exposure declines quality of early embryos and disrupts placental structure by destabilizing Notch signaling pathway

Project description:Nicotine is a common environmental pollution which is diffused into the air in the form of cigarette smoke fumes. Due to its lipophilic nature, nicotine can rapidly transport through membrane barriers and spread throughout the body which leads to abnormalities in the human brain, heart and even the fatal. However, the effects of nicotine on early embryonic development remains elusive. In this study, we found that nicotine significantly affected early embryonic development with decreased blastocyst formation. In addition, embryos treated with nicotine caused increased level of ROS, DNA damage and cell apoptosis. By RNA sequencing analysis, we demonstrated that nicotine affected the expression of placental development genes. Consistently, we found that the placental development at E17.5 was impaired by nicotine exposure, with increased placental weight and disrupted placental structure. This was due to excessive activation of the Notch signaling pathway, since blocking Notch signal by DAPT treatment recovered abnormal placental weight and structure induced by nicotine exposure. We also observed that nicotine exposure could specifically cause promoter hypermethylation of Phlda2 (a maternally expressed imprinted gene associated with placental development) and lead to its abnormal expression. Overall, this study provides evidence that nicotine causes the declining quality of early embryo and leads to placental abnormalities related with over-activation of the Notch signaling pathway.

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