Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Interleukin-34-dependent perivascular macrophages promote vascular function in the brain

ABSTRACT: Interleukin-34-dependent perivascular macrophages promote vascular function in the brain

PROVIDER: PRJNA1237864 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR32761086.fastq.gz	Fastqsanger.gz
	SRR32761087.fastq.gz	Fastqsanger.gz
	SRR32761088.fastq.gz	Fastqsanger.gz
	SRR32761089.fastq.gz	Fastqsanger.gz

Items per page:

1 - 4 of 4

Similar Datasets

Interleukin-34-dependent perivascular macrophages promote vascular function in the brain

Project description:The development of most macrophages depends on the colony-stimulating factor 1 (CSF-1) receptor, which has two ligands: CSF-1 and interleukin-34 (IL-34). While IL-34 is required for the homeostasis of microglia, the parenchymal macrophages in the central nervous system (CNS), it is unclear whether brain border-associated macrophages (BAMs) also depend on this cytokine. Here, we demonstrated that the embryonic development of murine BAMs in the choroid plexus, leptomeninges, and perivascular spaces required CSF-1, while IL-34 was critical for their maintenance in adulthood. In the brain, Il34 was expressed by mural cells and perivascular fibroblasts, and its transgenic deletion in these cells interrupted BAM maintenance. Il34-deficiency coincided with transcriptional changes in vascular cells, leading to increased flow velocity and vasomotion in pial and penetrating arterioles. Similarly, Mrc1CreCsf1rfl/fl mice lacking CD206+ perivascular BAMs exhibited increased hemodynamics in arterial networks. These findings reveal a crosstalk between vascular cells and CNS macrophages regulating cerebrovascular function.

2025-03-23 | GSE292306 | GEO

Interleukin-34-dependent perivascular macrophages promote vascular function in the brain [10X_IL34KOandWT_macrophages_vascular_cells]

2025-03-27 | GSE292466 | GEO

Interleukin-34-dependent perivascular macrophages promote vascular function in the brain [10X_IL34KOandWT_macrophages_vascular_cells]

Project description:Interleukin-34-dependent perivascular macrophages promote vascular function in the brain [10X_IL34KOandWT_macrophages_vascular_cells]

| PRJNA1238813 | ENA

Primitive macrophages promote a perivascular niche to enable vascular perfusion in human cardiac tissue

Project description:Primitive macrophages promote a perivascular niche to enable vascular perfusion in human cardiac tissue

| PRJNA1003900 | ENA

RNA-seq of human U87MG-GFP perivascular glioma stem cells

Project description:Glioblastoma stem cells (GSCs) have been reported to be found near the blood vessels. We wanted to identify the perivascular GSCs by combining the label retention approach with vascular perfusion. GSCs, like most of the stem cells, are in a quiescent state. Label retention approach involves staining the cells with a uniform membrane labeling dye (PKH26) and allowing them to grow in vivo in NOD SCID mice. Slow-dividing stem cells will retain the dye to a greater extent and perivascular cells are identified by injecting the mice with vascular perfusion dye (Hoechst 33342) 5 min prior to sacrifice. Perivascular GSCs (positive for Hoechst 33342 and pKH26 dye - dubbed as H+P+) were compared with the rest of the perivascular glioma cells (H+P-).

2022-01-01 | E-MTAB-9607 | biostudies-arrayexpress

Excitatory Neuron-Derived Interleukin-34 Controls Cortical Developmental Microglia Function

Project description:Excitatory Neuron-Derived Interleukin-34 Controls Cortical Developmental Microglia Function

| PRJNA1230265 | ENA

Beiging of perivascular adipose tissue regulates its inflammation and vascular remodeling

Project description:Although inflammation plays critical roles in the development of atherosclerosis, its regulatory mechanisms remain incompletely understood. Perivascular adipose tissue (PVAT) has been reported to undergo inflammatory changes in response to vascular injury. Here, we showed that vascular injury induced the beiging (brown adipose tissue-like phenotype change) of PVAT, which fine-tunes inflammatory response and thus vascular remodeling as a protective mechanism. In a mouse model of endovascular injury, macrophages accumulated in PVAT, causing beiging phenotype change. Inhibition of PVAT beiging by genetically silencing PRDM16, a key regulator to beiging, exacerbated inflammation and vascular remodeling following injury. Conversely, activation of PVAT beiging attenuated inflammation and pathological vascular remodeling. Single-cell RNA sequencing revealed that beige adipocytes abundantly expressed neuregulin 4 (Nrg4) which critically regulated alternative macrophage activation. Importantly, significant beiging was observed in the diseased aortic PVAT in patients with acute aortic dissection. Taken together, vascular injury induced the beiging of adjacent PVAT with macrophage accumulation, where NRG4 secreted from the beige PVAT facilitated alternative activation of macrophages, leading to the resolution of vascular inflammation. Our study demonstrated the pivotal roles of PVAT in vascular inflammation and remodeling and will open a new avenue for treating atherosclerosis.

2022-06-21 | GSE206399 | GEO

Mutation in the rat interleukin 34 gene impacts macrophage development, homeostasis and inflammation

Project description:The roles of Interleukin 34 in rat macrophage function

| PRJEB90514 | ENA

Beiging of perivascular adipose tissue regulates its inflammation and vascular remodeling

Project description:Beiging of perivascular adipose tissue regulates its inflammation and vascular remodeling

| PRJNA850433 | ENA

Vascular EC-derived factors promote DPC functions.

Project description:Vascular EC-derived factors promote DPC functions.

| PRJNA1189533 | ENA