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Interleukin-34-dependent perivascular macrophages promote vascular function in the brain [10X_IL34KOandWT_macrophages_vascular_cells]

ABSTRACT: Interleukin-34-dependent perivascular macrophages promote vascular function in the brain [10X_IL34KOandWT_macrophages_vascular_cells]

PROVIDER: PRJNA1238813 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR32788661.fastq.gz	Fastqsanger.gz
	SRR32788662.fastq.gz	Fastqsanger.gz
	SRR32788663.fastq.gz	Fastqsanger.gz
	SRR32788664.fastq.gz	Fastqsanger.gz

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Interleukin-34-dependent perivascular macrophages promote vascular function in the brain

Project description:The development of most macrophages depends on the colony-stimulating factor 1 (CSF-1) receptor, which has two ligands: CSF-1 and interleukin-34 (IL-34). While IL-34 is required for the homeostasis of microglia, the parenchymal macrophages in the central nervous system (CNS), it is unclear whether brain border-associated macrophages (BAMs) also depend on this cytokine. Here, we demonstrated that the embryonic development of murine BAMs in the choroid plexus, leptomeninges, and perivascular spaces required CSF-1, while IL-34 was critical for their maintenance in adulthood. In the brain, Il34 was expressed by mural cells and perivascular fibroblasts, and its transgenic deletion in these cells interrupted BAM maintenance. Il34-deficiency coincided with transcriptional changes in vascular cells, leading to increased flow velocity and vasomotion in pial and penetrating arterioles. Similarly, Mrc1CreCsf1rfl/fl mice lacking CD206+ perivascular BAMs exhibited increased hemodynamics in arterial networks. These findings reveal a crosstalk between vascular cells and CNS macrophages regulating cerebrovascular function.

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Interleukin-34-dependent perivascular macrophages promote vascular function in the brain

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Interleukin-34-dependent perivascular macrophages promote vascular function in the brain [10X_IL34KOandWT_macrophages_vascular_cells]

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