Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

High-Resolution Spatial Map of the Human Facial Sebaceous Gland Reveals Marker Genes and Decodes Sebocyte Differentiation [MERFISH]

ABSTRACT: High-Resolution Spatial Map of the Human Facial Sebaceous Gland Reveals Marker Genes and Decodes Sebocyte Differentiation [MERFISH]

PROVIDER: PRJNA1238306 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Similar Datasets

High-Resolution Spatial Map of the Human Facial Sebaceous Gland Reveals Marker Genes and Decodes Sebocyte Differentiation [MERFISH]

Project description:The sebaceous gland is essential for skin homeostasis by producing sebum to lubricate and protect the skin. However, its cellular and molecular mechanisms in humans remain poorly understood as most studies have been conducted in mouse models. This study provides a comprehensive molecular analysis of the human sebaceous gland, focusing on cellular interactions, novel gene markers, and sebocyte differentiation. By integrating Stereo-seq spatial transcriptomics, single-cell RNA sequencing, and validation though MERFISH, we identified four distinct stages of sebocyte differentiation, each characterized by unique gene signatures. These results reveal sebocyte differentiation as a dynamic and complex process. Our findings enhance the understanding of sebaceous gland biology and provide a valuable reference for future research and the development of therapies for sebaceous gland-related disorders, including acne.

2025-04-23 | GSE292394 | GEO

High-Resolution Spatial Map of the Human Facial Sebaceous Gland Reveals Marker Genes and Decodes Sebocyte Differentiation

2025-04-23 | GSE292156 | GEO

High-Resolution Spatial Map of the Human Facial Sebaceous Gland Reveals Marker Genes and Decodes Sebocyte Differentiation

Project description:High-Resolution Spatial Map of the Human Facial Sebaceous Gland Reveals Marker Genes and Decodes Sebocyte Differentiation

| PRJNA1237296 | ENA

Identification of genes involved in sebaceous gland carcinoma of the eyelid

Project description:Sebaceous gland carcinoma is the frequent malignant tumor of the eyelid. However, there is limited understanding of how altered gene expression of sebaceous gland carcinoma of the eyelid related to the pathogenesis. In this study, to identify genes involved in sebaceous gland carcinoma of the eyelid, global-scale gene expression analysis was carried out using a GeneChip® system.

2019-01-25 | GSE125582 | GEO

qMAP decodes RNA fragmentation dynamics

Project description:qMAP decodes RNA fragmentation dynamics

| PRJNA1465826 | ENA

Sebaceous Neoplasm Tissue Study, 20190101

Project description:Sebaceous Neoplasm Tissue Study, 20190101

| PRJNA1085409 | ENA

Sebaceous Neoplasm Tissue Study, 20190101

Project description:Sebaceous Neoplasm Tissue Study, 20190101

| PRJNA1085410 | ENA

MERFISH reveals embryonic endothelial heterogeneity

Project description:MERFISH reveals embryonic endothelial heterogeneity

| PRJNA1038713 | ENA

MERFISH profiling of mouse retinal ganglion cell layer on wholemount

Project description:We optimized a workflow combining imaging-based spatial transcriptomics (MERFISH) and immunostaining on ganglion cell layer retinal flatmounts of C57/Bl6J mice.The MERFISH data shows molecularly-defined retinal ganglion cell types types exhibited non-uniform distributions. We also analyzed local neighborhoods for each cell and registered several RGC types as enriched in the perivascular niche.

2025-07-23 | GSE303399 | GEO

Sebaceous gland atrophy in psoriasis: An explanation for psoriatic alopecia?

Project description:In a transcriptome study of psoriatic (PP) vs. normal (NN) skin, we found a co-expressed gene module (N5) enriched 11.5-fold for lipid biosynthetic genes. We also observed fewer visible hairs in PP skin, compared to uninvolved (PN) or NN skin (p<0.0001). To ask whether these findings might be due to abnormalities of the pilosebaceous unit, we carried out 3D morphometric analysis of paired PP and PN biopsies. Sebaceous glands (SG) were markedly atrophic in PP vs. PN skin (91% average reduction in volume, p=0.031). Module N5 genes were strongly downregulated in PP vs. NN skin (fold-change [FC] < 0.25, 44.4-fold), and strongly up-regulated in sebaceous hyperplasia (SH, FC > 4, 54.1-fold). The intersection of PP-downregulated and SH-upregulated gene lists generated a gene expression signature consisting solely of module N5 genes, whose expression in PP vs. NN skin was inversely correlated with the signature of IL17-stimuated keratinocytes. Despite loss of visible hairs, morphometry identified elongated follicles in PP vs. PN skin (average 1.7 vs. 1.2 Jm, p=0.020). These results document SG atrophy in non-scalp psoriasis, identify a cytokine-regulated set of SG signature genes, and suggest that loss of visible hair in PP skin may result from abnormal SG function. Gene expression was compared between sebaceous hyperplasia lesions (n = 5) and normal skin (n = 3) from control subjects.

2016-06-02 | E-GEOD-82140 | biostudies-arrayexpress

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data