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RNA-seq analysis in hepatocyte-specific Atg7-knockout mice with different p62 mutations

ABSTRACT: RNA-seq analysis in hepatocyte-specific Atg7-knockout mice with different p62 mutations

PROVIDER: PRJNA1241166 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR32841142.fastq.gz	Fastqsanger.gz
	SRR32841143.fastq.gz	Fastqsanger.gz
	SRR32841144.fastq.gz	Fastqsanger.gz
	SRR32841145.fastq.gz	Fastqsanger.gz
	SRR32841146.fastq.gz	Fastqsanger.gz

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RNA-seq analysis in hepatocyte-specific Atg7-knockout mice with different p62 mutations [RNA-seq_S351A]

Project description:RNA-seq analysis in hepatocyte-specific Atg7-knockout mice with different p62 mutations [RNA-seq_S351A]

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RNA-seq analysis in hepatocyte-specific Atg7-knockout mice with different p62 mutations [RNA-seq_T352A]

Project description:RNA-seq analysis in hepatocyte-specific Atg7-knockout mice with different p62 mutations [RNA-seq_T352A]

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RNA-seq analysis in hepatocyte-specific Atg7-knockout mice with different p62 mutations [RNA-seq_T352A]

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RNA-seq analysis in hepatocyte-specific Atg7-knockout mice with different p62 mutations [RNA-seq_S351A]

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Proteome analysis in hepatocyte-specific Atg7-knockout mice with different p62 mutations

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Gene expression profiles in livers caused by Atg7 and/or Nrf2 deficiency

Project description:Autophagy deficiency caused by conditional knockout of Atg7 results in severe hepatitis accompanied by abundant accumulation of p62. p62 stablizes Nrf2 by disrupting the association between Keap1 and Nrf2. To understand the pathogenesis of hepatitis under the autophagy deficiency, we examined gene expression profiles of livers from Atg7-null, Nrf2-null and Atg7-Nrf2 double mutant mice. Eight week old Atg7F/F:Mx1-Cre mice and Atg7F/F:Mx1-Cre:Nrf2-/- together with control mice were injected with pIpC. At 4 weeks after pIpC injection, total RNAs were purified from each mouse liver.

2010-10-14 | E-GEOD-20415 | biostudies-arrayexpress

RNA-seq analysis in hepatocyte-specific Atg7-knockout mice with different p62 mutations

Project description:This SuperSeries is composed of the SubSeries listed below.

2025-04-24 | GSE292739 | GEO

Gene expression profiles in livers caused by Atg7 and/or Nrf2 deficiency

2010-10-15 | GSE20415 | GEO

Spatial transcriptomics of Atg7 knockout mice reveals ATG7’s role in antimicrobial immunity against nontuberculous mycobacteria

Project description:We performed Spatial transcriptomics (Visium) using the 10X Genomics platform to investigate the role of the autophagy-related protein ATG7 in the context of nontuberculous mycobacterial (NTM) infection. ATG7 in innate immune cells plays a critical role in controlling NTM infection and protecting lung tissue from pathological inflammation. This study represents single-cell analysis of Mice deletion of Atg7 in innate immune cells and reveals the importance of ATG7 in mediating antimicrobial responses during infection and its essential role in host defense mechanisms against NTM.

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Expression data from NexCre:Atg7 conditional knockout mice brain

Project description:Transcriptome analysis of NesCre:Atg7 conditional knockout mice. Autophagy plays an important role in regulating protein metabolism and tissue homeostasis. Recent studies have reported that neural stem cell-specific Atg7 knockout mice (NesCre:Atg7f/f cKO mice) exhibit neonatal lethal due to severe neurodegeneration. However, the precise mechanisms of how neuronal fate is regulated by the autophagic pathway have not been elucidated. Here, we performed microarray experiments to analyze the changes in gene expression patterns in NesCre:Atg7 cKO mice. As a result, we could find a lot of candidate genes changed by Atg7 deficiency.

2022-10-07 | GSE214939 | GEO

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