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RNA-seq analysis in hepatocyte-specific Atg7-knockout mice with different p62 mutations [RNA-seq_T352A]

ABSTRACT: RNA-seq analysis in hepatocyte-specific Atg7-knockout mice with different p62 mutations [RNA-seq_T352A]

PROVIDER: PRJNA1241176 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR32840252.fastq.gz	Fastqsanger.gz
	SRR32840253.fastq.gz	Fastqsanger.gz
	SRR32840254.fastq.gz	Fastqsanger.gz
	SRR32840255.fastq.gz	Fastqsanger.gz
	SRR32840256.fastq.gz	Fastqsanger.gz

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RNA-seq analysis in hepatocyte-specific Atg7-knockout mice with different p62 mutations

Project description:RNA-seq analysis in hepatocyte-specific Atg7-knockout mice with different p62 mutations

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RNA-seq analysis in hepatocyte-specific Atg7-knockout mice with different p62 mutations [RNA-seq_S351A]

Project description:RNA-seq analysis in hepatocyte-specific Atg7-knockout mice with different p62 mutations [RNA-seq_S351A]

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RNA-seq analysis in hepatocyte-specific Atg7-knockout mice with different p62 mutations [RNA-seq_S351A]

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Proteome analysis in hepatocyte-specific Atg7-knockout mice with different p62 mutations

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Gene expression profiles in livers caused by Atg7 and/or Nrf2 deficiency

Project description:Autophagy deficiency caused by conditional knockout of Atg7 results in severe hepatitis accompanied by abundant accumulation of p62. p62 stablizes Nrf2 by disrupting the association between Keap1 and Nrf2. To understand the pathogenesis of hepatitis under the autophagy deficiency, we examined gene expression profiles of livers from Atg7-null, Nrf2-null and Atg7-Nrf2 double mutant mice. Eight week old Atg7F/F:Mx1-Cre mice and Atg7F/F:Mx1-Cre:Nrf2-/- together with control mice were injected with pIpC. At 4 weeks after pIpC injection, total RNAs were purified from each mouse liver.

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RNA-seq analysis in hepatocyte-specific Atg7-knockout mice with different p62 mutations

Project description:This SuperSeries is composed of the SubSeries listed below.

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Single-cell RNA-seq of Atg7 knockout mice reveals ATG7’s role in antimicrobial immunity against nontuberculous mycobacteria

Project description:We performed single-cell RNA sequencing (scRNA-seq) using the 10X Genomics platform to investigate the role of the autophagy-related protein ATG7 in the context of nontuberculous mycobacterial (NTM) infection. ATG7 in innate immune cells plays a critical role in controlling NTM infection and protecting lung tissue from pathological inflammation. This study represents single-cell analysis of Mice deletion of Atg7 in innate immune cells and reveals the importance of ATG7 in mediating antimicrobial responses during infection and its essential role in host defense mechanisms against NTM.

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