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Upregulated Natriuretic Peptide B expression as a hallmark of chronic itch

ABSTRACT: Upregulated Natriuretic Peptide B expression as a hallmark of chronic itch

PROVIDER: PRJNA1247404 | ENA |

REPOSITORIES: ENA

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Upregulated Natriuretic Peptide B expression as a hallmark of chronic itch

Project description:To examine transcriptional plasticity in sensory neurons, we performed bulk RNA-sequencing studies on dorsal root ganglia from an atopic dermatitis-like mouse and a contact dermatitis monkey model.

2025-08-06 | GSE293900 | GEO

Impairment of cardiac natriuretic peptide signaling develops the excessive cardiac hypertrophy during lactation period

Project description:Two natriuretic peptides, atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP) act through the common receptor, guanylyl cyclase-A (GC-A) to lower blood pressure, induce diuresis/natriuresis and dilate blood vessels. Recently, we discovered that the excessive cardiac hypertrophy accompanied with cardiac dysfunction was induced in the lactating natriuretic peptide receptor 1 (Npr1, which encodes GC-A)-deficient mice. To clarify the cause of lactation-induced cardic hypertrophy in Npr1-/-, we performed the gene expressions analysis using nulliparous (NP) or postpartum lactating wild-type (Npr1+/+) and Npr1-/- mice. Numerous genes were altered in the postpartum lactating period both in Npr1+/+ and Npr1-/-. Additionally, the involvement of inflammatory responce in the cardiac hypertrophy in lactating-Npr1-/- mice was clarified bythe gene ontology analysis.

2019-09-01 | GSE84744 | GEO

Natriuretic Peptide Receptor 3 (NPR3) is regulated by microRNA-100

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Tmem45b Modulates itch via Endoplasmic Reticulum Calcium Regulation

Project description:Chronic itch is detected by dorsal root ganglia (DRG) that severely impairs quality of life. However, its underlying mechanisms remain poorly understood. We identified that Tmem45b was contained in natriuretic peptide type B (Nppb)-, mas-related G-protein coupled receptor member A3 (Mrgpra3)-, and Mrgprd-positive DRG neurons, which are associated with itch sensation. The role of Tmem45b in itch sensation has not been explored. Tmem45b conditional knockout (cKO) mice exhibited decreased scratching to β-alanine, and increased scratching to chloroquine. Notably, Tmem45b cKO alleviated chronic itch. Furthermore, Tmem45b cKO impaired the calcium response to β-alanine and allyl isothiocyanate but not to chloroquine in dissociated DRG neurons. Tmem45b deficiency led to significant downregulation of sarco/endoplasmic reticulum calcium transport ATPase 1 (Serca1), impairing calcium storage capacity of endoplasmic reticulum (ER). Inhibition of Serca1 in DRG neurons reduced intracellular calcium release triggered by β-alanine and chloroquine. Together,Tmem45b deficiency may reduce nonhistaminergic itch and disrupt ER calcium regulation, highlighting a potential target for chronic itch therapy.

2026-01-01 | GSE304359 | GEO

Beige Fat, Energy, and the Natriuretic Peptide System

Project description:Beige Fat, Energy, and the Natriuretic Peptide System

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Beige Fat, Energy, and the Natriuretic Peptide System

Project description:The purpose of this study is to learn how types of fat profiles differ between lean and obese individuals, and how they differ between racial groups. We are also interested in learning about the relationship of fat profiles with natriuretic peptide hormones, which are hormones produced by the heart. We will measure this by collecting tissue, blood and urine samples, energy expenditure measurements using the metabolic cart, and a DXA to assess the amount of bone, fat and muscle in the body from a single study visit.

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Identification of natriuretic peptide receptor A (NPR-A) expression signatures in podocytes in vivo reveals baseline control of protective pathways including Protein S

Project description:Natriuretic peptide receptor-A (NPR-A) is the principal receptor for the natriuretic peptides ANP and BNP. Targeted deletion of NPR-A in mouse glomerular podocytes significantly enhances renal injury in vivo in the DOCA-salt experimental model. It was therefore hypothesized that natriuretic peptides exert a direct protective effect on glomerular barrier integrity through activation of NPR-A and modulation of gene expression patterns in podocytes. RNA-seq analysis revealed a total of 158 DEGs with 81 downregulated DEGs and 77 upregulated DEGs in Npr1 deficient podocytes. Among the downregulated genes were protein S and semaphorin 3G, which are known to have a protective effect in podocytes. Protein S was also expressed in and secreted from isolated human glomeruli. GO enrichment analysis revealed that the upregulated DEGs in NPR-A deficient podocytes were associated with cell migration and motility. In line, BNP significantly decreased podocyte outgrowth from cultured glomeruli.

2024-10-02 | GSE249221 | GEO

Cardiac specific deletion of natriuretic peptide receptor A induces different myocardial expression of circular RNA and mRNA involved with metabolism in mice

Project description:Atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP) are not only important biological markers, but also regulators of cardiac functions. The natriuretic peptide A receptor (NPRA), also called NPR1 or guanylyl cyclase A (GC-A), binds with ANP or BNP ligand and fulfils transmembrane signalling transduction by elevating the intracellular levels of cGMP. However, the comprehensive effects and mechanisms downstream to NPRA are still largely to be elucidated. Here, the cardiac expressing profiles of mRNA in the mice with myocardium-specific deletion of NPRA were analyzed. It was found that differently expressed mRNAs were detected and proved by Gene Ontology (GO) and pathway analysis to be mainly related to the metabolic process. Moreover, circular RNAs (circRNAs) were scrutinized, and subsequently a possible regulatory network consisting of circRNAs- MicroRNAs (miRNAs) -mRNAs was predicted and constructed by ceRNA (competing endogenous RNA) analysis. In conclusion, NPRA plays possible roles in cardiac metabolism, which might be mediated by circRNAs via endogenous competition mechanisms.

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Collagen-binding C-type natriuretic peptide enhances chondrogenesis and osteogenesis

Project description:Collagen-binding C-type natriuretic peptide enhances chondrogenesis and osteogenesis

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IL-33-activated calcitonin gene-related peptide-producing memory Th2 cells co-operate with somatosensory neurons to induce conjunctival itch

Project description:Allergic conjunctivitis is a chronic inflammatory disease that is characterized by severe itch in the conjunctiva; but how neuro-immune interactions shape the pathogenesis of severe itch remains unclear. We identified a subset of memory-type pathogenic Th2 cells that preferentially expressed Il1rl1-encoding ST2 and Calca-encoding calcitonin gene-related peptide (CGRP) in the inflammatory conjunctiva using a single-cell analysis. The IL-33-ST2 axis in memory Th2 cells controlled the axonal elongation of the peripheral sensory C-fiber and the induction of severe itch. Pharmacological blockade and genetic deletion of CGRP signaling in vivo attenuated scratching behavior. The analysis of giant papillae from patients with severe allergic conjunctivitis revealed ectopic lymphoid structure formation with the accumulation of IL-33-producing epithelial cells and CGRP-producing pathogenic CD4+ T cells accompanied by peripheral nerve elongation. Thus, the IL-33-ST2-CGRP axis directs severe itch with neuro-reconstruction in the inflammatory conjunctiva and is a potential therapeutic target for severe itch in allergic conjunctivitis.

2022-05-20 | GSE203217 | GEO

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