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Bulk mRNAseq in control and Cnp-Cre_RelA cKO mouse spinal cords

ABSTRACT: Bulk mRNAseq in control and Cnp-Cre_RelA cKO mouse spinal cords

PROVIDER: PRJNA1248979 | ENA |

REPOSITORIES: ENA

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Bulk mRNAseq in control and Cnp-Cre_RelA cKO mouse spinal cords

Project description:We sequenced mRNA extracted from the cerebral cortices including hippocampi of mice at postnatal day 14 (P14) and compared the gene expression levels between the control group and the RelA conditional knockout (Cnp-Cre; RelA cKO) group.

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Bulk mRNAseq in control and Plp-CreER_Ddx20 cKO mouse spinal cords

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Transcriptome of murine lumbar spinal cord at E12.5 in control and DOT1L cKO through Wnt1cre2 (B6.Cg-E2f1Tg(Wnt1-cre)2Sor/J, Jackson Laboratory #022501)

Project description:DOT1L has a proven function in the cortical and cerebellar development of the mouse model, but has never been studied in the developing spinal cord. Here, we created a transgenic mouse line for Dot1l conditional knock-out in the spinal cord over neurogenesis. We investigated the changes in the trascriptome by performing bulk RNAseq of lumbar spinal cords in controls and Dot1l-cKO. The DEG analysis of cKO littermates revealed a higher degree of differentiation profile as opposed to the controls, concurrent with decreased cell proliferation and altered axonal projection and interneuron migration, supporting the importance of DOT1L activity in the developing spinal cord.

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CLIPseq of hnRNP A1 from the spinal cords of mice with experimental autoimmune encephalomyelitis

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scRNAseq from spinal cords of SOD1-G93A and WT mice

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Genome wide analysis of upper spinal cords with training after spinal cord hemisection injury

Project description:The goal of this study is to elucidate the influence of treadmill training on transcriptome of the upper lumbar spinal cord after thoracic spinal cord hemisection. mRNA profiles of spinal cords at 23 days-post injury with/without treadmill training were generated. The expression levels of 650 genes in the trained animal were increased ( > 2-fold) compared to untrained animals. Our study represents the detailed analysis of transcriptomes of spinal cord distal to the hemisected lesion after treadmill training, with biologic replicates, generated by RNA-seq technology.

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Genome wide analysis of lower spinal cords with training after spinal cord hemisection injury

Project description:The goal of this study is to elucidate the influence of treadmill training on transcriptome of the lower lumbar spinal cord after thoracic spinal cord hemisection. mRNA profiles of spinal cords at 23 days-post injury with/without treadmill training were generated. The expression levels of 650 genes in the trained animal were increased ( > 2-fold) compared to untrained animals. Our study represents the detailed analysis of transcriptomes of spinal cord distal to the hemisected lesion after treadmill training, with biologic replicates, generated by RNA-seq technology.

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