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Single-cell RNA seq of ipsilateral L4-L6 DRGs from rats in both Sham and CPIP group

ABSTRACT: Single-cell RNA seq of ipsilateral L4-L6 DRGs from rats in both Sham and CPIP group

PROVIDER: PRJNA1250505 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR33133711_1.fastq.gz	Fastqsanger.gz
	SRR33133711_2.fastq.gz	Fastqsanger.gz
	SRR33133712_1.fastq.gz	Fastqsanger.gz
	SRR33133712_2.fastq.gz	Fastqsanger.gz
	SRR33133713_1.fastq.gz	Fastqsanger.gz

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Single-cell RNA seq of ipsilateral L4-L6 DRGs from rats in both Sham and CPIP group

Project description:Complex regional pain syndrome type-I (CRPS-I) is chronic neurological disorder accompanied with devastating pain. In this study, we employed single-cell sequencing technology to analyze the ipsilateral L4-L6 dorsal root ganglia in both Sham and CPIP groups, aiming to investigate the mechanisms underlying chronic pain development in the CPIP model.

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High-throughput unbiased RNA-Sequencing (RNA-Seq) to profile gene expression in ipsilateral L4-L6 DRG obtained from rats of Sham+Veh, CPIP+Veh and CPIP+ETA groups

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High-throughput unbiased RNA-Sequencing (RNA-Seq) to profile gene expression in ipsilateral L4-L6 DRG obtained from rats of Sham+Veh, CPIP+Veh and CPIP+ETA groups

Project description:Since TNF-α is a pro-inflammatory cytokine that can promote neuroinflammation to mediate chronic pain, we then explored which signaling molecules or pathways in DRG were affected by TNF-α and contributed to neuroinflammation in CPIP condition.

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Expression from L4/5 DRGs after oral administration of LBP

Project description:Current study found that oral administration markedly increased the growth capacity of DRG neurons. In this dataset, we identified genes that were differentially expressed in L4/5 DRGs after oral administration of LBP

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Expression from L4/5 DRGs after oral administration of LBP

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Conditional deletion of miR-21 in sensory neurons is associated with gene changes in macrophages isolated from L4/L5 ipsilateral DRG

Project description:A microarray analysis (MA) on the F4/80+ CD11b+ macrophages (population P5) isolated from a pool of ipsilateral L4/L5 DRG in spared nerve injured WT and miR-21 cKO

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Lumbar 5 (L5) nerve compression affects adjacent DRGs and distal nerve

Project description:Painful radiculopathy, mainly caused by physical damage to spinal nerve roots, brings algesia in their innervated areas. Intriguingly, the region of paresthesia is not always limited to the injured neuron-innervated area, and abnormal activation is also frequently observed in adjacent intact nerve segments. Since injured and uninjured nerve fibers comingle in one nerve trunk, we propose a hypothesis that the compression of the spinal nerve produces a degenerative environment at the distal end of the nerve, affecting the undamaged nerve fibers. We divided the rats into two groups: Compression of L5 spinal nerve in the experimental group and sham operation in the sham group. DRGs of L4, L5 and L6, femoral nerve and sciatic nerve were collected for RNA-seq. The results showed that L5 nerve compression resulted in inflammatory response in adjacent non-injured L4 DRG. The femoral nerve and sciatic nerve showed signs of nerve damage and repair. This suggests that injured nerve fibers can influence the properties of adjacent intact fibers through the nerve trunk which they converge.

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Project description:Complex regional pain syndrome type-I (CRPS-I) is chronic neurological disorder accompanied with devastating pain. Most conventional medical treatments lack effectiveness, making CRPS-I a challenging clinical condition. Electroacupuncture (EA) showed effectiveness in alleviating the pain symptoms of CRPS-I patients. However, the molecular mechanisms underlying EA’s therapeutic effect are still not well understood. Here, we established the rat chronic post-ischemic pain (CPIP) model to mimic CRPS-I and performed repetitive EA on bilateral hind limbs of the CPIP model rats. We then performed RNA-sequencing (RNA-Seq) to study the differences in gene expression, gene networks and molecular pathways in ipsilateral DRGs innervating the hind limb of the CPIP model rats with and without repetitive EA treatment. Our results found that repetitive EA treatment significantly alleviated mechanical allodynia in bilateral hind limbs of CPIP model rats. RNA-Seq analysis indicated that EA modulated the expression of multiple genes and gene networks in the DRGs of CPIP model rats. Further bioinformatics analysis identified the up-regulation of an array of genes involved in biological process such as neutrophil chemotaxis and immune response in the DRGs of CPIP model rats after EA treatment. Thus, these results suggest that EA may alleviate pain response in CPIP model rats via regulating multiple genes. Our work may help to further advance the understandings of the molecular mechanisms underlying EA’s therapeutic effects on CRPS-I and help to identify novel targets for CRPS-I treatment

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Expression changes in L4 DRG initiated by sciatic nerve injury

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