Project description:Labial gland tissues were obtained from three individuals diagnosed with pSS and three healthy donors. All participants were recruited from the Rheumatology and Immunology Department of Kunshan First People's Hospital during 2022.
Project description:Carbapenem-resistant Klebsiella pneumoniae (CRKP), particularly the K64 serotype, poses a severe clinical threat due to its high virulence and multidrug resistance. In this study, we investigated the gene expression profiles of host lung tissues to understand the pathogenesis of K64-CRKP infection and the therapeutic mechanism of Dep44, a capsule-degrading depolymerase. An acute pneumonia mouse model was established via intranasal infection with K64-CRKP. We performed high-throughput RNA sequencing (RNA-seq) on lung tissues from four experimental groups: the negative control group (healthy mice), the positive control group (K64-CRKP infected model), the treatment group (infected mice treated with Dep44), and the drug control group (healthy mice treated with Dep44). The analysis aims to elucidate the host immune response to K64-CRKP infection and evaluate how Dep44 treatment modulates these transcriptomic changes to exert its therapeutic effect.
2025-12-02 | GSE311904 | GEO
Project description:Salmonella outbreak vet hospital 2022
| PRJNA1054585 | ENA
Project description:Human metapneumovirus genomes from Lima, Peru (2022-2024)
| PRJNA1233817 | ENA
Project description:CRKP
| PRJNA1207320 | ENA
Project description:CRKP
| PRJNA778807 | ENA
Project description:CRKP
| PRJNA1209626 | ENA
Project description:Genomic surveillance of respiratory viruses USA:WA 2022-2024
