Project description:Detailed exploration was performed on the T cell and B cell transcriptional profiles when comparing moderate and severe patients to healthy donors, identifying candidate gene signatures. Furthermore, we analyzed the properties of cytotoxicity and exhaustion within T cell subgroups derived from CRKP samples.
Project description:Meropenem is one of the main antibiotics used in the clinical treatment of CRKP. This study demonstrated that some important metabolic changes occurred in Meropenem-induced CRKP-OMVs, The OMVs proteome expression profile indicates increased secretion of stress proteins released from Meropenem-induced Klebsiella pneumoniae. Furthermore, this is the first study to discuss the protein-protein interaction network of the OMVs released by CRKP, especially under antibiotic stress.
