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The transcriptome of playfulness is sex-biased in the juvenile rat medial amygdala: a role for inhibitory neurons

ABSTRACT: The transcriptome of playfulness is sex-biased in the juvenile rat medial amygdala: a role for inhibitory neurons

PROVIDER: PRJNA1254641 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR33291239_1.fastq.gz	Fastqsanger.gz
	SRR33291239_2.fastq.gz	Fastqsanger.gz
	SRR33291240_1.fastq.gz	Fastqsanger.gz
	SRR33291240_2.fastq.gz	Fastqsanger.gz
	SRR33291241_1.fastq.gz	Fastqsanger.gz

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The transcriptome of playfulness is sex-biased in the juvenile rat medial amygdala: a role for inhibitory neurons

Project description:Social play is a well-conserved, dynamic behavior known to be sexually differentiated. In most species, males play more than females, a sex difference largely driven by the medial amygdala (MeA) yet the full mechanism establishing this bias is unknown. Here, we explore “the transcriptome of playfulness” in both sexes for the first time, demonstrating that the transcriptomic profile in the juvenile rat MeA associated with playfulness is markedly distinct in males and females. Parallel single-cell RNA-sequencing experiments from newborn rats suggest that inhibitory neurons drive this sex difference. Furthermore, we show that inhibitory neurons comprise the majority of play-active cells in the juvenile MeA, with males having more play-active cells than females, of which a greater proportion are GABAergic. Through integrative bioinformatic analyses, we further explore the expression, function, and cell-type specificity of key play-associated gene modules, providing valuable insight into the sex-biased mechanisms underlying this fundamental social behavior.

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The “play transcriptome” is sex-specific in the juvenile rat medial amygdala: a role for inhibitory neurons

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The “play transcriptome” is sex-specific in the juvenile rat medial amygdala: a role for inhibitory neurons

Project description:The “play transcriptome” is sex-specific in the juvenile rat medial amygdala: a role for inhibitory neurons

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Rat, male, brain, medial amygdala, LC-MSMS

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Project description:Sexual dimorphism in the brain is well-documented, yet clear binary features akin to genital differences remain elusive. Using the TRAP2 transgenic mouse line to track cFos-driven neuronal activity, we identified a distinct cluster of neurons (~200 µm) in the posterodorsal medial amygdala—termed the DIMPLE—that exhibited binary activation: consistently labeled in females but absent in adult virgin males. This pattern was unaffected by gonadectomy but was present in juvenile males before weaning and re-emerged in adult males after mating. Public RNA-seq data showed prolactin receptor enrichment in this region, and exogenous prolactin administration activated DIMPLE in virgin males. We propose that DIMPLE may support neural mechanisms related to female-typical behavior or paternal readiness.

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