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ABSTRACT: FM-HAA

PROVIDER: PRJNA1257376 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR33388237_1.fastq.gz	Fastqsanger.gz
	SRR33388237_2.fastq.gz	Fastqsanger.gz
	SRR33388238_1.fastq.gz	Fastqsanger.gz
	SRR33388238_2.fastq.gz	Fastqsanger.gz
	SRR33388239_1.fastq.gz	Fastqsanger.gz

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Project description:Circulating miRNA expression profiles were detected by microarray analysis.qPCR arrays were performed to validate the potential miRNAs.KEGG pathway analysis was used to determine the critical roles of these circulating miRNAs in FM. Correlation analysis was employed between miRNAs and the parameters of cardiac functions in FM. The sensitivity and specificity of circulating lncRNA expression in FM diagnosis were evaluated using receiver operating characteristic curve analysis. Microarray and qPCR analysis showed that the expression of miR-4763-3p and miR-4281 were up-regulated in the plasma of FM at the onset, and their levels were restored as the clinical symptom recovered. The predicted target genes of miR-4763-3p and miR-4281 are involved in several pathways, mainly inflammatory and cardiac injury response. Moreover, the miRNAs enrichment was negatively correlated with the severity of FM. In addition, the expression levels of circulating miR-4763-3p was unchanged in MI and patients and miR-4281 showed high sensitivity and specificity for FM diagnosis.This study provides global profile of circulating miRNAs in patients with FM, among which miR-4763-3p and miR-4281 could serve as potential biomarkers.

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