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A lysosomal surveillance response to stress extends healthspan [Exp3]

ABSTRACT: A lysosomal surveillance response to stress extends healthspan [Exp3]

PROVIDER: PRJNA1258196 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR33413962_1.fastq.gz	Fastqsanger.gz
	SRR33413962_2.fastq.gz	Fastqsanger.gz
	SRR33413963_1.fastq.gz	Fastqsanger.gz
	SRR33413963_2.fastq.gz	Fastqsanger.gz
	SRR33413964_1.fastq.gz	Fastqsanger.gz

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A lysosomal surveillance response to stress extends healthspan

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A lysosomal surveillance response to stress extends healthspan [Exp1]

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A lysosomal surveillance response to stress extends healthspan [Exp3]

Project description:Lysosomes are cytoplasmic organelles central for the degradation of macromolecules to maintain cellular homeostasis and health. However, how lysosomal activity can be boosted to counteract aging and aging-related diseases remains elusive. Here, we reveal that silencing specific vacuolar H+-ATPase subunits (e.g. vha-6), that are essential for intestinal lumen acidification in Caenorhabditis elegans, extends lifespan by ~60%. This longevity phenotype can be explained by an adaptive transcriptional response typified by induction of a set of transcripts involved in lysosomal function and proteolysis, which we termed the lysosomal surveillance response (LySR). LySR activation is characterized by boosted lysosomal activity, enhanced clearance of protein aggregates in worm models of Alzheimer's disease, Huntington’s disease and amyotrophic lateral sclerosis, thereby improving fitness. The GATA transcription factor ELT-2 governs the LySR program and its associated beneficial effects. Activating the LySR pathway may therefore represent an attractive mechanism to reduce proteotoxicity and, as such, potentially extend healthspan.

2025-05-03 | GSE296199 | GEO

A lysosomal surveillance response to stress extends healthspan [Exp2]

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A lysosomal surveillance response to stress extends healthspan [Exp1]

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A lysosomal surveillance response to stress extends healthspan

Project description:This SuperSeries is composed of the SubSeries listed below.

2023-02-03 | GSE196023 | GEO

Increased hyaluronan by naked mole-rat HAS2 extends healthspan in mice

Project description:Increased hyaluronan by naked mole-rat HAS2 extends healthspan in mice

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Increased hyaluronan by naked mole-rat HAS2 extends healthspan in mice

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Evolutionarily-conserved FOXO-regulated OSER1 extends lifespan and healthspan

Project description:Molecular aging reflects the time-dependent accumulation of cellular damage and loss of essential cellular functions. FOXO transcription factors and their downstream targets play critical roles in the response to aging-associated cellular damage. Here, we identify and characterize a novel FOXO-regulated stress response gene, Oxidative Stress Responsive Serine-rich Protein 1 (OSER1), whose level of expression dramatically influences lifespan in Bombyx mori, Caenorhabditis elegans, and Drosophila. Overexpression of OSER1 also enhances resistance to oxidative stress, starvation, and heat shock, whereas depletion increases susceptibility to these stressors. In humans, common OSER1 genetic variants are associated with longevity. These data show that OSER1 modulates the oxidative stress response and suggest that OSER1 is a potent positive regulator of lifespan and healthspan in multiple species.

2024-07-25 | PXD036579 | Pride

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