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Cxcr4 and Cxcr6 Dually Limits T Cell Entry Into the Polyomavirus-infected Brain

ABSTRACT: Cxcr4 and Cxcr6 Dually Limits T Cell Entry Into the Polyomavirus-infected Brain

PROVIDER: PRJNA1258981 | ENA |

REPOSITORIES: ENA

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Cxcr4 and Cxcr6 Dually Limits T Cell Entry Into the Polyomavirus-infected Brain

Project description:Regulation of the T cell response during viral infection of the central nervous system (CNS) is a vital aspect of host response for pathogen clearance but must be tightly regulated as to prevent excess inflammation and pathology. Chemokines are often cited as the source for control of both the CD8 and CD4 T cell response, modulating their migration and proliferation. Here mouse polyomavirus (MuPyV) is used as in vivo model for JCPyV, the causative agent of Progressive Multifocal Leukoencephalopathy (PML), to investigate the duel control of CXCR4 and CXCR6 on brain T cells. MERFISH single cell spital transcriptomes for the first time reveals the full landscape of MuPyV brain infection and genetic knockout and small molecule antagonists models divulge the T cell response control mechanism. This work points to the potential of new duel targeting therapeutic strategies for PML patients and contributes to central details about the functions of CXCR4 and CXCR6 that are required for full understanding of T cell responses in the CNS.

2025-06-25 | GSE296357 | GEO

Expression profile of CXCR6 Hi T cells or CXCR6 Lo helper T cells in CD45Rb Hi tranfer model mice

Project description:To identify the role of chemokine receptor in inflammation of colon, we isolated CD3+CD4+ helper T cells harboring CXCR6 from colonic lamina propria of mice We used microarrays to identify the differentially expressed genes between CXCR6Hi Tcells and CXCR6Lo Tcells CXCR6 Hi or CXCR6 Lo T cells were isolated from colonic lamina propria for RNA extraction and hybridization on Affymetrix microarrays.

2013-04-09 | E-GEOD-45881 | biostudies-arrayexpress

CXCR6 orchestrates brain CD8+ T cell residency and limits mouse Alzheimer’s disease pathology

Project description:CXCR6 orchestrates brain CD8+ T cell residency and limits mouse Alzheimer’s disease pathology

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Gene expression in human breast cancer cell lines regulated by CXCR6 gene

Project description:This study aimed to further our understanding of the role that CXCR6 plays in breast cancer progression. Microarrays were searched for some genes that had correlated expression with CXCR6 mRNA. According to fold-change screening between restoring expression of CXCR6 and its respective control cells in MDA-MB-231 and MCF-7 cells, both up-regulated and down-regulated genes were shown. The restoring of CXCR6 expression in MDA-MB-231 and MCF-7 cells were respectively noted as MDA-MB-231-CXCR6 and MCF-7-CXCR6 cells and the respective controls were noted as MDA-MB-231-GFP and MCF-7-GFP cells.

2015-06-30 | E-GEOD-60484 | biostudies-arrayexpress

CXCR6 orchestrates brain CD8+ T cell residency and limits mouse Alzheimer’s disease pathology [microarray]

Project description:CXCR6 orchestrates brain CD8+ T cell residency and limits mouse Alzheimer’s disease pathology [microarray]

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CXCR6 orchestrates brain CD8+ T cell residency and limits mouse Alzheimer’s disease pathology [scRNA-seq1]

Project description:CXCR6 orchestrates brain CD8+ T cell residency and limits mouse Alzheimer’s disease pathology [scRNA-seq1]

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CXCR6 orchestrates brain CD8+ T cell residency and limits mouse Alzheimer’s disease pathology [scRNA-seq4]

Project description:CXCR6 orchestrates brain CD8+ T cell residency and limits mouse Alzheimer’s disease pathology [scRNA-seq4]

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CXCR6 orchestrates brain CD8+ T cell residency and limits mouse Alzheimer’s disease pathology [scRNA-seq3]

Project description:CXCR6 orchestrates brain CD8+ T cell residency and limits mouse Alzheimer’s disease pathology [scRNA-seq3]

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CXCR6 orchestrates brain CD8+ T cell residency and limits mouse Alzheimer’s disease pathology [scRNA-seq2]

Project description:CXCR6 orchestrates brain CD8+ T cell residency and limits mouse Alzheimer’s disease pathology [scRNA-seq2]

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Human hematopoietic leukemic k562 cells: control Vs CXCR4 constitutively active mutant cells

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2016-02-29 | E-GEOD-76544 | biostudies-arrayexpress

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