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ABSTRACT: Liver ischemia reperfusion mice

PROVIDER: PRJNA1266403 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR33673678_1.fastq.gz	Fastqsanger.gz
	SRR33673679_1.fastq.gz	Fastqsanger.gz
	SRR33673680_1.fastq.gz	Fastqsanger.gz
	SRR33673681_1.fastq.gz	Fastqsanger.gz
	SRR33673682_1.fastq.gz	Fastqsanger.gz

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Ischemic Pre- and Post Conditioning has pronounced effects on Gene Expression Profiles in the Rat Liver after Ischemia/Reperfusion

Project description:Ischemia/reperfusion injuries is a known complication to hepatic surgery. Ischemic pre- (IPC) and postconditioning (IPO) protects the liver against ischemia/reperfusion-injuries. Expression profiling were performed on liver biopsies seeking to identify molecular mediators of the protective properties. 48 rats were divided into 5 groups; sham (n=8), IRI (n=10), IPC (n=10), IPO (n=10) and IPC+IPO (n=10). All rats except sham rats were subjected to 30 min of total liver ischemia and 30 min of reperfusion before liver biopsies were sampled. In the IPC group, liver ischemia was preceded by 10 min of hepatic ischemia, followed by 10 min of reperfusion. IPO were performed by three cycles of 30 sec of reperfusion and 30 sec of ischemia, applied immediately after the 30 min of total liver ischemia. In the IPC+IPO group the two interventions were combined.

2011-09-30 | E-GEOD-24430 | biostudies-arrayexpress

Ischemic Pre- and Post Conditioning has pronounced effects on Gene Expression Profiles in the Rat Liver after Ischemia/Reperfusion

2011-10-01 | GSE24430 | GEO

Expression profiling of long noncoding RNAs in mouse liver tissue

Project description:Long noncoding RNA profile in the liver after ischemia-reperfusion injury (IRI).

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Transcriptomic analysis of liver lymphatic endothelial cell isolated from sham or ischemia/reperfusion (I/R) mouse model

Project description:This study aims to determine changes in transcriptomic profiles in lymphatic vessels in response to ischemia-reperfusion injury, which mimics conditions in liver transplantation. This experiment will determine the potential role of lymphatic vessels during the ischemia-reperfusion injury in the liver.

2024-08-19 | GSE255346 | GEO

To determine whether interference with mechanisms of vasoconstriction or inflammation would improve outcomes in ischemia reperfusion injury of the liver

Project description:Study was performed in groups of animals including healthy controls, ischemia reperfusion alone, and administration of drug followed by ischemia reperfusion. Samples from liver and isolated hepatocytes intact and one day after reperfusion were analyzed for gene expression in conjunction with other biological variables. Results indicated substantive alteration after drug intervention in multiple gene ontology groups and cellular events and processes after ischemia reperfusion.

2020-07-01 | GSE78038 | GEO

METTL3 deficiency aggravates hepatic ischemia/reperfusion injury in mice by activating the MAPK signaling pathway

Project description:Inflammatory responses, apoptosis, and oxidative stress, are key factors that contribute to hepatic ischemia/reperfusion (I/R) injury, which may lead to the failure of liver surgeries, such as hepatectomy and liver transplantation. The N6-methyladenosine (m6A) modification has been implicated in multiple biological processes, and its specific role and mechanism in hepatic I/R injury require further investigation. We found that METTL3 may be involved in regulating this process. Therefore, we constructed an ischemia-reperfusion model with Hepatocyte-specific METTL3 knockdown (HKD) mice, and performed RNA- sequencing analysis with wild-type mice as controls.

2024-04-22 | GSE252255 | GEO

Integrative Analysis of the Roles of lncRNAs and mRNAs in Ischaemic Preconditioning to Alleviate Liver Ischaemia–Reperfusion Injury in Mice

Project description:schemic preconditioning (IPC) has been developed for protection of liver from ischemia reperfusion injury, which results in tolerance to subsequent insults of ischemia. But little is known about the underlying biological pathophysiology of long non-coding RNAs (lncRNAs) in the liver ischemia-reperfusion (I/R) injury. Our study aims to provide a mechanism for the function of IPC against liver I/R injury and to giving rise to new research perspectives of lncRNAs. In this study, 18 mice (C57BL/6) were involved and randomly divided into the following groups (6 mice per group): the Sham group, the I/R group, and I/R+IPC group. Serum and liver tissue samples were collected for analysis from a mouse liver model of I/R injury and I/R+IPC. Then we randomly selected 5 mice per group and extracted their liver samples for microarray analysis and subsequent bioinformatics analysis.

2025-01-01 | GSE192977 | GEO

Rat liver tissue: IR vs. iPoC

Project description:microRNAs expression of rat liver tissue comparing ischemia-reperfusion (IR) group with ischemic postconditioning(iPoC) group

2019-12-02 | GSE56071 | GEO

LncRNA and mRNA profiling of the ischemia zone, the border zone and the remote non-ischemia zone of murine myocardial ischemia/reperfusion (MI/R) hearts

Project description:Purpose：Detection of differentially expressed lncRNA in the infarct zone and the control group in myocardial ischemia-reperfusion injury model tissue. Method: Use 8 weeks of C57BL/6 mice to establish a myocardial ischemia-reperfusion injury model, 45 minutes of ischemia, and 24 hours after reperfusion, the mice were sacrificed to obtain materials. Result: The expression of lncRNAs in the infarct area of myocardial ischemia-reperfusion injury model mice was detected, and it was found that a total of 43 lncRNAs related to myocardial ischemia-reperfusion injury changed in expression, of which 17 were up-regulated (fold change >1.5). 26 expressions are down-regulated (fold change <0.8)

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Project description:To identify the role of mRNA during myocardial ischemia-reperfusion in mice, we have employed high-throughput sequencing to detect mRNA expression. Samples were collected from the control group and the ischemia reperfusion groups , with 5 samples per group. The candidate mRNA that may affect the process of myocardial ischemia-reperfusion was screened by comparing the ischemia-reperfusion group and the control group.

2023-11-15 | GSE223343 | GEO

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