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ABSTRACT: Transcriptomic Analysis of Gallic Acid-Treated Thyroid Cancer Cells

PROVIDER: PRJNA1280496 | ENA |

REPOSITORIES: ENA

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			Action	DRS
		Other
	SRR34091309_1.fastq.gz	Fastqsanger.gz
	SRR34091309_2.fastq.gz	Fastqsanger.gz
	SRR34091311_1.fastq.gz	Fastqsanger.gz
	SRR34091311_2.fastq.gz	Fastqsanger.gz

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Gene Expression Profile Analysis of Gallic Acid-induced Cell Death Process

Project description:Gallic acid is a natural phenolic compound that displays anti-cancer properties in clinically relevant cell culture and rodent models. To date, the molecular mechanism governing the gallic acid-induced cancer cell death process is largely unclear, thus hindering development of novel therapeutics. Therefore, we performed time-course long non-coding RNA sequencing (lncRNA-seq) to reveal the gene expression profiles at the early, middle, and late stages of the gallic acid-induced cell death process in human cervical cancer HeLa cells. This work provides a dataset with differentially expressed genes across different stages of cell death process during the gallic acid induction, which is important for further study on the control of this cell death mechanism.

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Expression data from 5azaC- or gallic acid-treated human lung cancer H1299 cell line

Project description:Gallic acid (also known as 3,4,5-trihydroxybenzoic acid, GA), a naturally occurring phenolic acid, is a major constituent of tea and red wine. It has been demonstrated that GA possess anti-cancer activities. We found the epigenetic effect of GA in tobacco-associated human cancer cell lines. In this dataset, we include the expression array data from human lung cancer H1299 cell line with or without the treatment of 5azaC or GA. These data were used to obtain genes upregulated in both 5azaC- orGA-treated H1299 cells.

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