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IL-26 from ILCs regulates early-life gut epithelial homeostasis by shaping microbiota composition III

ABSTRACT: IL-26 from ILCs regulates early-life gut epithelial homeostasis by shaping microbiota composition III

PROVIDER: PRJNA1281660 | ENA |

REPOSITORIES: ENA

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IL-26 from ILCs regulates early-life gut epithelial homeostasis by shaping microbiota composition III

Project description:Animals host symbiotic microbial communities that shape gut health. However, how the host immune system and microbiota interact to regulate epithelial homeostasis, particularly during early development, remains unclear. Human interleukin-26 (IL-26) is associated with gut inflammation and has intrinsic bactericidal activity in vitro, yet its in vivo functions are largely unknown, primarily due to its absence in rodents. To examine the role of IL-26 in early life, we used zebrafish and found that gut epithelial cells in il26-/- larvae exhibited increased proliferation, faster turnover, elevated and DNA damage response, and altered cell population abundance. This epithelial dysregulation occurred independently of the IL-26 canonical receptor and resulted from dysbiosis in il26-/-. Moreover, IL-26 bactericidal activity was conserved in zebrafish, suggesting a potential role of this property in regulating microbiota composition. We further identified innate lymphoid cells (ILCs) as the primary source of IL-26 at this developmental stage. These findings establish IL-26 as a central player in a regulatory circuit linking the microbiota, ILCs, and intestinal epithelial cells to maintain gut homeostasis during early life.

2025-07-01 | GSE300683 | GEO

IL-26 from ILCs regulates early-life gut epithelial homeostasis by shaping microbiota composition IV

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IL-26 from ILCs regulates early-life gut epithelial homeostasis by shaping microbiota composition II

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IL-26 from ILCs regulates early-life gut epithelial homeostasis by shaping microbiota composition I

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IL-26 from ILCs regulates early-life gut epithelial homeostasis by shaping microbiota composition IV

Project description:IL-26 from ILCs regulates early-life gut epithelial homeostasis by shaping microbiota composition IV

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IL-26 from ILCs regulates early-life gut epithelial homeostasis by shaping microbiota composition I

Project description:IL-26 from ILCs regulates early-life gut epithelial homeostasis by shaping microbiota composition I

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IL-26 from ILCs regulates early-life gut epithelial homeostasis by shaping microbiota composition II

Project description:IL-26 from ILCs regulates early-life gut epithelial homeostasis by shaping microbiota composition II

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Single cell RNA-sequencing of human tonsil Innate lymphoid cells (ILCs)

Project description:Single cell RNA-sequencing of human tonsil Innate lymphoid cells (ILCs) from three independent tonsil donors. Sequencing libraries were prepared from FACS sorted individual ILCs with the Smart-Seq2 protocol (Picelli et al. Nature Methods 2013)

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Single cell RNAseq gut ILCs

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Single cell RNAseq gut ILCs

Project description:We have generated 10x scRNA-seq of ILCs purified from small intestine and colon of WT mice

2019-11-22 | GSE132273 | GEO