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IL-26 from ILCs regulates early-life gut epithelial homeostasis by shaping microbiota composition II

ABSTRACT: IL-26 from ILCs regulates early-life gut epithelial homeostasis by shaping microbiota composition II

PROVIDER: PRJNA1281661 | ENA |

REPOSITORIES: ENA

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IL-26 from ILCs regulates early-life gut epithelial homeostasis by shaping microbiota composition II

Project description:Animals host symbiotic microbial communities that shape gut health. However, how the host immune system and microbiota interact to regulate epithelial homeostasis, particularly during early development, remains unclear. Human interleukin-26 (IL-26) is associated with gut inflammation and has intrinsic bactericidal activity in vitro, yet its in vivo functions are largely unknown, primarily due to its absence in rodents. To examine the role of IL-26 in early life, we used zebrafish and found that gut epithelial cells in il26-/- larvae exhibited increased proliferation, faster turnover, elevated and DNA damage response, and altered cell population abundance. This epithelial dysregulation occurred independently of the IL-26 canonical receptor and resulted from dysbiosis in il26-/-. Moreover, IL-26 bactericidal activity was conserved in zebrafish, suggesting a potential role of this property in regulating microbiota composition. We further identified innate lymphoid cells (ILCs) as the primary source of IL-26 at this developmental stage. These findings establish IL-26 as a central player in a regulatory circuit linking the microbiota, ILCs, and intestinal epithelial cells to maintain gut homeostasis during early life.

2025-07-01 | GSE300682 | GEO

IL-26 from ILCs regulates early-life gut epithelial homeostasis by shaping microbiota composition I

2025-07-01 | GSE300679 | GEO

IL-26 from ILCs regulates early-life gut epithelial homeostasis by shaping microbiota composition IV

2025-07-01 | GSE300684 | GEO

IL-26 from ILCs regulates early-life gut epithelial homeostasis by shaping microbiota composition III

2025-07-01 | GSE300683 | GEO

IL-26 from ILCs regulates early-life gut epithelial homeostasis by shaping microbiota composition I

Project description:IL-26 from ILCs regulates early-life gut epithelial homeostasis by shaping microbiota composition I

| PRJNA1281659 | ENA

IL-26 from ILCs regulates early-life gut epithelial homeostasis by shaping microbiota composition III

Project description:IL-26 from ILCs regulates early-life gut epithelial homeostasis by shaping microbiota composition III

| PRJNA1281660 | ENA

IL-26 from ILCs regulates early-life gut epithelial homeostasis by shaping microbiota composition IV

Project description:IL-26 from ILCs regulates early-life gut epithelial homeostasis by shaping microbiota composition IV

| PRJNA1281657 | ENA

IL-1beta, IL-23, and TGF-beta drive plasticity of human ILC2s towards IL-17-producing ILCs in nasal inflammation

Project description:Innate lymphoid cells (ILCs) are crucial for the immune surveillance at mucosal sites. ILCs coordinate early eradication of pathogens and contribute to tissue healing and remodelling, features that are dysfunctional in patients with cystic fibrosis (CF). The mechanisms by which ILCs contribute to CF-immunopathology are ill-defined. Here, we report that group 2 ILCs (ILC2s) transdifferentiated into IL-17-secreting cells in the presence of the epithelial derived-cytokines IL-1β, IL-23 and TGF-β. This conversion was abrogated by IL-4 or vitamin D3. IL-17 producing ILC2s induced IL-8 secretion by epithelial cells and their presence in nasal polyps of CF patients is associated with neutrophilia. Our data suggest that ILC2s undergo transdifferentiation in CF nasal polyps in response to local cytokines, which are induced by infectious agents.

2019-03-26 | GSE124926 | GEO

Single cell RNA-sequencing of human tonsil Innate lymphoid cells (ILCs)

Project description:Single cell RNA-sequencing of human tonsil Innate lymphoid cells (ILCs) from three independent tonsil donors. Sequencing libraries were prepared from FACS sorted individual ILCs with the Smart-Seq2 protocol (Picelli et al. Nature Methods 2013)

2016-01-27 | E-GEOD-70580 | biostudies-arrayexpress

Single cell RNAseq gut ILCs

Project description:Single cell RNAseq gut ILCs

| PRJNA547481 | ENA