Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

IL-25-induced effector-memory ILC2s mediate small intestinal adaptation [scRNA-Seq 2]

ABSTRACT: IL-25-induced effector-memory ILC2s mediate small intestinal adaptation [scRNA-Seq 2]

PROVIDER: PRJNA1287816 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Similar Datasets

IL-25-induced effector-memory ILC2s mediate small intestinal adaptation [ATAC-seq]

Project description:IL-25-induced effector-memory ILC2s mediate small intestinal adaptation [ATAC-seq]

| PRJNA1288253 | ENA

IL-25-induced effector-memory ILC2s mediate small intestinal adaptation [scRNA-seq]

Project description:IL-25-induced effector-memory ILC2s mediate small intestinal adaptation [scRNA-seq]

| PRJNA1288260 | ENA

IL-25-induced effector-memory ILC2s mediate small intestinal adaptation [scRNA-Seq 1]

Project description:IL-25-induced effector-memory ILC2s mediate small intestinal adaptation [scRNA-Seq 1]

| PRJNA1287815 | ENA

IL-25-induced effector-memory ILC2s mediate small intestinal adaptation [ATAC-seq]

Project description:This study used bulk ATAC sequencing of either small intestinal ILC2s or Lgr5+ epithelial stem cells +50 days after an IL-25 regimen or PBS regimen in wild type (ILC2s) or Lgr5DTR-EGFP (epithelial stem cells) mice to study chromatin accessibility.

2025-07-28 | GSE301998 | GEO

IL-25-induced effector-memory ILC2s mediate small intestinal adaptation [scRNA-Seq 2]

Project description:This study used single cell RNA sequencing of small intestinal ILC2s +50 days after an IL-25 regimen or PBS regimen in wild type and Il25-/- mice to study memory ILC2 gene signatures.

2025-07-28 | GSE301976 | GEO

Retinoic acid drives intestine-specific adaptation of effector ILC2s originating from distant sites [scRNA-Seq]

Project description:Adaptation of immune cells to tissue-specific microenvironments is a crucial process in homeostasis and inflammation. Here, we show that murine effector type 2 innate lymphoid cells (ILC2s) from various organs are equally effective in repopulating ILC2 niches in other anatomical locations where they adapt tissue-specific phenotypes of target organs. Single-cell transcriptomics of ILC2 populations revealed upregulation of retinoic acid (RA) signaling in ILC2s during adaptation to the small intestinal microenvironment, and RA signaling mediated reprogramming of kidney effector ILC2s towards the small intestinal phenotype in vitro and in vivo. Inhibition of intestinal ILC2 adaptation by blocking RA signaling impaired worm expulsion during Strongyloides ratti infection, indicating functional importance of ILC2 tissue imprinting. In conclusion, this study highlights that effector ILC2s retain the ability to adapt to changing tissue-specific microenvironments, enabling them to exert tissue-specific functions, such as promoting control of intestinal helminth infections.

2023-09-15 | GSE242569 | GEO

IL-25-induced effector-memory ILC2s mediate small intestinal adaptation [scRNA-Seq 1]

Project description:This study used single cell RNA sequencing of small intestinal ILC2s +60 days after helminth infection (Nippostrongylus brasiliensis-Nb. or Heligmosomoides polygyrus, Hp.) and in age matched naïve mice (Ctrl) to study memory ILC2 gene signatures after helminth infection.

2025-07-28 | GSE301975 | GEO

Retinoic acid drives intestine-specific adaptation of effector ILC2s originating from distant sites [bulk RNA-Seq]

2023-09-15 | GSE242562 | GEO

IL-25-induced effector-memory ILC2s mediate small intestinal adaptation [scRNA-seq]

Project description:This study used single cell RNA sequencing of small intestinal epitheilal cells +50 days after an IL-25 regimen or PBS regimen in wild type mice to study long-term changes in gene expression by epitheilal cells.

2025-07-28 | GSE301999 | GEO

Differential activation of human ILC2s by IL-25 and IL-33

Project description:The epithelial cell derived cytokines IL-25 and IL-33 can both activate type 2 innate lymphoid cells (ILC2s). It is not known whether the actions of these cytokines on ILC2s are similar or divergent. To investigate this we performed in vitro culture of human ILC2s with a variety of cytokine combinations including IL-2, IL-7, IL-25 and IL-33. Transcriptome profiling of these different condtions allowed us to assess the impact on gene expression of the different treatments. The results show that IL-25 and IL-33 promote divergent gene expression programs indicating that differential expression of these cytokines can cause diverse ILC2 effector function.

2017-08-01 | GSE72433 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data