Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

TCR sequences of peripheral blood CD8+ T cells and regulatory T cells before and after chemoimmunotherapy in KORNELIA phase II trial

ABSTRACT: TCR sequences of peripheral blood CD8+ T cells and regulatory T cells before and after chemoimmunotherapy in KORNELIA phase II trial

PROVIDER: PRJNA1288402 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Similar Datasets

TCR sequences of peripheral blood CD8+ T cells and regulatory T cells before and after chemoimmunotherapy in KORNELIA phase II trial

Project description:We aimed to analyze the effects of chemoimmunotherapy on peripheral blood T cell clonotypes in HER2-negative breast cancer patients.

2025-07-29 | GSE302042 | GEO

RNA-seq on human regulaotry T cells before and after TCR stimulation

Project description:RNA-seq on human regulaotry T cells before and after TCR stimulation

| PRJEB83653 | ENA

Trial

Project description:Trial Trial

| PRJEB7892 | ENA

Sequential chemoimmunotherapy in gastric cancer

Project description:Sequential pembrolizumab cooperates with platinum/5FU to remodel the tumor immune microenvironment in advanced gastric cancer: A phase II sequential chemoimmunotherapy trial

| PRJEB58725 | ENA

Coupling of response biomarkers between tumour and peripheral blood in patients undergoing chemoimmunotherapy

Project description:Platinum-based chemotherapy in combination with anti-PD-L1 antibodies has shown promising results in mesothelioma. However, the immunological mechanisms underlying its efficacy are not well understood and there are no predictive biomarkers to guide treatment decisions. Here, we combine time-course RNA sequencing of peripheral blood mononuclear cells with pre-treatment tumour transcriptome data from the 54-patient single arm phase II DREAM study. Single cell RNA-seq and TCR-seq reveal CD8+ T effector memory (TEM) cells with stem-like properties are more abundant in peripheral blood of responders and this population expands upon treatment. These peripheral blood changes are linked to the transcriptional state of the tumour microenvironment. Combining information from both compartments, rather than individually, is most predictive of response. Our study highlights the complex, but predictive interactions between the tumour and immune cells in peripheral blood during the response to chemoimmunotherapy.

2024-10-31 | GSE252990 | GEO

TCR

Project description:TCR

2021-07-15 | OEX00013711 | NODE

DNA methylation analysis overtime in chronic lymphocytic leukemia cases treated with chemoimmunotherapy

Project description:The contribution of DNA methylation on the evolution of chronic lymphocytic leukemia has not been adequately studied yet. The purpose of this study was to investigate the role of DNA methylation in patients under chemoimmunotherapy. The overtime analysis of DNA methylation was performed on 40 patients in two time points: pre-treatment and after relapse, and 2 samples of memory B cells (MBC), using 450k arrays.

2019-12-10 | E-MTAB-7575 | biostudies-arrayexpress

Coupling of response biomarkers between tumour and peripheral blood in patients undergoing chemoimmunotherapy II

2024-10-31 | GSE253173 | GEO

Gene expression profiles in CLL

Project description:Evaluation of differential expression between CLL patients in a chemoimmunotherapy trial with age-matched controls

2010-06-25 | GSE22529 | GEO

APMAT analysis reveals associations between antigen-TCR sequences and CD8 T cell phenotype in COVID-19 patients

Project description:Here, we describe Antigen-TCR Pairing and Multiomic Analysis of T-cells (APMAT), which is an integrated experimental-computational framework designed for the high-throughput capture and analysis of antigen specific CD8 T cells, with paired antigen, TCR sequence, and transcriptome information from the same single cells, from many patient samples in parallel.

2024-09-18 | E-MTAB-14002 | biostudies-arrayexpress

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data