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Divergent cytokine and transcriptional signatures control functional T follicular helper cell heterogeneity (scRNAseq/CITEseq)

ABSTRACT: Divergent cytokine and transcriptional signatures control functional T follicular helper cell heterogeneity (scRNAseq/CITEseq)

PROVIDER: PRJNA1291653 | ENA |

REPOSITORIES: ENA

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Divergent cytokine and transcriptional signatures control functional T follicular helper cell heterogeneity (scRNAseq/CITEseq)

Project description:CD4+ T follicular helper (Tfh) cells support tailored B cell responses against multiple classes of pathogens. To reveal how diverse Tfh phenotypes are established, we profiled Tfh cells in response to viral, helminth and bacterial infection. We identified a core Tfh signature that is distinct from CD4+ T follicular regulatory and effector cells and identified pathogen-specific transcriptional modules that shape Tfh function. Cytokine-transcriptional Tfh programming demonstrated that type I interferon and TGFbeta signaling direct individual Tfh phenotypes to instruct B cell output. Cytokine-directed Tfh transcriptional phenotypes are shared within human germinal centers (GCs), but distinct Tfh phenotypes dominate between donors and following immune challenge or in antibody-mediated disease. Finally, we identified novel cell surface markers that align with distinct Tfh phenotypes. Thus, we provide a comprehensive resource of Tfh diversity in humans and mice, to enable immune monitoring during infection and disease and to inform the development of context-specific vaccines.

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Murine follicular helper T cells

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Expression Data from in vivo follicular helper CD4 T cells (TFH) versus non follicular helper CD4 T cells (non-TFH)

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Divergent cytokine and transcriptional signatures control functional T follicular helper cell heterogeneity (RNAseq)

Project description:Divergent cytokine and transcriptional signatures control functional T follicular helper cell heterogeneity (RNAseq)

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Differential Expression of IL-2 Defines CD4 T cells fated for Follicular Helper and Non-follicular Helper Development (RNA-Seq)

Project description:IL-2 production defines precursors fated to become T Follicular Helper cells

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Differential Expression of IL-2 Defines CD4 T cells fated for Follicular Helper and Non-follicular Helper Development (ATAC-Seq)

Project description:IL-2 production defines precursors fated to become T Follicular Helper cells

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