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Homo sapiens

ABSTRACT: Gene expression profiles of MCF-7 cells treated with Si-Wu-Tang, estradiol and ferulic acid

OTHER RELATED OMICS DATASETS IN: E-GEOD-23610

PROVIDER: PRJNA129951 | ENA |

REPOSITORIES: ENA

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E-GEOD-23610

Project description:Gene expression profiles of MCF-7 cells treated with Si-Wu-Tang, estradiol and ferulic acid

2025-01-24 | E-GEOD-23610 | ExpressionAtlas

Gene expression profiles of MCF-7 cells treated with Si-Wu-Tang, estradiol and ferulic acid

2011-05-18 | GSE23610 | GEO

Gene expression profiles of MCF-7 cells treated with Si-Wu-Tang, estradiol and ferulic acid

Project description:Traditional Chinese medicines (TCM), usually composed of a mixture of components, may simultaneously target multiple genes/pathways and thus achieve superior efficacy for complex diseases such as cancer. To identify novel mechanisms of action and potential health benefits for a TCM formula Si-Wu-Tang (SWT) widely used for womenâs health, we obtained the DNA microarray expression profiles for SWT, its active component ferulic acid, and estradiol in human breast cancer cell line MCF-7 and analyzed the gene expression signatures associated with each treatment using the âConnectivity Mapâ (cMAP). This study indicates that DNA microarray profiling analysis and cMAP data mining provide a powerful approach to discover unknown mechanisms of actions and identify potential new health benefits for TCM. We profiled the gene expression of MCF-7 cell lines to SWT, its active component FA, as well as estradiol using Affymetrix human genome U133 plus 2.0 arrays. The data set includes profiles for 24 samples, divided into eight groups of treatment: 0.001% DMSO used as the vehicle control (C), 0.1 ÂµM estradiol (EM), FA at three concentrations (0.1, 1, and 10 ÂµM) (FL, FM and FH) and SWT at three concentrations (0.0256, 0.256, and 2.56 mg/ml) (SL, SM and SH). For each treatment group, 3 biological replicates were included, resulting in 24 (8 groups Ã 3 replicates/group) RNA samples.

2011-05-18 | E-GEOD-23610 | biostudies-arrayexpress

Expression data from ferulic acid treated C. elegans

Project description:Gene expression in N2 worms treated with 500 μM or 0 μM ferulic acid, at days 5. Effects of ferulic acid in C. elegans gene expression is studied, as our results indicate a lifespan extension effect produced by this molecule. RNA-seq were used to detail the global programme of gene expression underlying the lifespan extension and identified distinct classes of up/down-regulated genes in animals treated with ferulic acid.

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RNA sequencing of HSCs from ctrl mice or long-term ferulic acid treated mice

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Project description:Single-cell RNA sequencing (scRNA-seq) on MCF-7 breast cancer cells treated with fulvestrant or 17-β estradiol, and MCF-7 cell line derivatives made resistant to fulvestrant.

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Autotoxicity mechanism of Oryza Sativa: Microarray analysis of rice plants in response to allelochemical ferulic acid

Project description:Autotoxicity plays an important mechanism in regulating plant productivity. Ferulic acid (FA) is phytotoxic and was identified in extracts and residues of rice plants as a candidate for rice allelochemicals. To help characterize the autotoxicity mechanism of rice, we present the first large-scale, transcriptomic analysis of rice root responses to ferulic acid. Two-condition experiment, short exposures and long exposures. Comparison of mock control and rice seedlings treated with 50 ppm ferulic acid (FA) during short (pooled from 1- and 3-h treatments), as compared to long (24 h) exposures.; Biological replicates: 3 control replicates (short and long exposures), 3 FA-treated replicates (short and long exposures).

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Wei2019 - Mathematical modeling of tumor growth The MCF-7 breast cancer cell line

Project description:This is a mathematical model describing MCF-7 cancer cell growth with interaction between tumor cells, estradiol (hormone-dependent tumor growth), natural killer cells, cytotoxic T lymphocytes and white blood cells.

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Role of SUMOylation in differential ERα transcriptional repression by SERMs and pure antiestrogens in breast cancer cells

Project description:RNA-seq: Gene expression profiling in MCF-7 cells treated with vehicle (0), estradiol (E2), the Selective ER Modulator 4-hydroxytamoxifen (OHT), or the pure antiestrogen fulvestrant (ICI). ChIP-seq: Genome-wide DNA binding profile of ERα and SUMO2/3 in MCF-7 cells treated with vehicle, E2 or ICI.

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Global transcriptomic analysis of the response of Corynebacterium glutamicum to ferulic acid

Project description:Corynebacterium glutamicum can survive by using ferulic acid as the sole carbon source. In this study, we assessed the response of C.glutamicum to ferulic acid stress by means of a global transcriptional response analysis. The transcriptional data showed that several genes involved in degradation of ferulic acid were affected. Moreover, several genes related to the stress response; protein protection or degradation and DNA repair; replication, transcription and translation; and the cell envelope were differentially expressed. Deletion of the katA or sigE gene in C. glutamicum resulted in a decrease in cell viability under ferulic acid stress. These insights will facilitate further engineering of model industrial strains, with enhanced tolerance to ferulic acid to enable easy production of biofuels from lignocellulose.

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