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Mesoscale proximity labeling at chromatin to study small molecule mechanism of action [MNase-seq]

ABSTRACT: Mesoscale proximity labeling at chromatin to study small molecule mechanism of action [MNase-seq]

PROVIDER: PRJNA1301275 | ENA |

REPOSITORIES: ENA

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Mesoscale proximity labeling at chromatin to study small molecule mechanism of action [MNase-seq]

Project description:Proximity labeling traditionally identifies interactomes of a single protein or RNA, though this approach limits mechanistic understanding of biomolecules functioning within complex systems. Here, we demonstrate a strategy for deciphering ligand-induced changes to global biomolecular interactions by enabling proximity labelling at the mesoscale, across an entire cellular system. By inserting nanoscale proximity labelling catalysts throughout chromatin, this system, MesoMap, provided new insights into how HDAC inhibitors regulate gene expression. Furthermore, it revealed that the orphaned drug candidate, SR-1815, regulates disease-linked Syngap1 gene expression through direct inhibition of kinases implicated in both neurological disorders and cancer. Through precise mapping of global chromatin mobility, MesoMap promotes insights into how drug-like chemical probes induce transcriptional dynamics within healthy and disease-associated cellular states.

2025-08-08 | GSE304411 | GEO

Mesoscale proximity labeling at chromatin to study small molecule mechanism of action [CUTandTag_1]

Project description:Mesoscale proximity labeling at chromatin to study small molecule mechanism of action [CUTandTag_1]

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Mesoscale proximity labeling at chromatin to study small molecule mechanism of action [RNAseq_4h_782]

Project description:Mesoscale proximity labeling at chromatin to study small molecule mechanism of action [RNAseq_4h_782]

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Mesoscale proximity labeling at chromatin to study small molecule mechanism of action [RNAseq_2wk_736]

Project description:Mesoscale proximity labeling at chromatin to study small molecule mechanism of action [RNAseq_2wk_736]

| PRJNA1301262 | ENA

Mesoscale proximity labeling at chromatin to study small molecule mechanism of action [CUTandTag_2]

Project description:Mesoscale proximity labeling at chromatin to study small molecule mechanism of action [CUTandTag_2]

| PRJNA1301263 | ENA

Mesoscale proximity labeling at chromatin to study small molecule mechanism of action [CUTandTag_1]

2025-08-08 | GSE304409 | GEO

Mesoscale proximity labeling at chromatin to study small molecule mechanism of action [RNAseq_4h_782]

2025-08-08 | GSE304413 | GEO

Mesoscale proximity labeling at chromatin to study small molecule mechanism of action [RNAseq_2wk_736]

2025-08-08 | GSE304412 | GEO

Mesoscale proximity labeling at chromatin to study small molecule mechanism of action [CUTandTag_2]

2025-08-08 | GSE304410 | GEO

MesoMap: Mesoscale proximity labeling of chromatin for small molecule mechanism of action

Project description:Mesoscale proximity labeling of chromatin is used to understand the impact that inhibitors have on chromatin structure and dynamics. We use uMap proximity labeling, distributed throughout chromatin to study how HDAC inhibition alters interactions. We then apply this approach to de-orphan a high throughput screening hit SR1815. We show that SR1815 is a kinase inhibitor that hits CLK proteins and alters RNA splicing.

2025-07-24 | MSV000098636 | MassIVE

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