ABSTRACT: Early Diagnosis of Streptococcus cristatus in Blood Culture-Negative Infective Endocarditis by Capture-Based Metagenomic Next-Generation Sequencing: A Case Report
Project description:Diagnosis of infective endocarditis by using metagenomic next-generation sequencing
| PRJNA784716 | ENA
Project description:Serial Targeted Next-Generation Sequencing Guides Diagnosis and Monitors Therapeutic Response in Culture-Negative Hypervirulent Klebsiella pneumoniae Pneumonia: A Case Report
Project description:Infective endocarditis is a severe disease caused by the infection of heart valves and endocardium by pathogenic germ. Antimicrobial therapy and surgery remain the basis of treatment, and up to 50% of the patients require surgical replacement of the affected valves to control the infectious source. The objective of this work is to identify the existence of endotypes in a prospective cohort of patients with infective endocarditis. We performed a bulk RNA-seq form peripheral blood to cluster patients according to their transcriptomic profiles at diagnosis and during their follow-up. Clinical data, outcomes and response to surgery were assessed in a cluster-specific manner, in order to identify differences in the pathogenesis that could help to find personalized treatments and improve the outcome.
Project description:Infective endocarditis is a severe disease caused by the infection of heart valves and endocardium by pathogenic germ. Antimicrobial therapy and surgery remain the basis of treatment, and up to 50% of the patients require surgical replacement of the affected valves to control the infectious source. The objective of this work is to identify the existence of endotypes in a prospective cohort of patients with infective endocarditis. We performed a bulk RNA-seq form peripheral blood to cluster patients according to their transcriptomic profiles at diagnosis and during their follow-up. Clinical data, outcomes and response to surgery were assessed in a cluster-specific manner, in order to identify differences in the pathogenesis that could help to find personalized treatments and improve the outcome.
Project description:Application of Loop-Mediated Isothermal Amplification and Next-Generation Sequencing in the Diagnosis of Maternal Tuberculosis with Multiple Negative Tests: A Case Report
| PRJNA755812 | ENA
Project description:An endocarditis caused by Thalassospira sp.: a case report
