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Rejuvenation of mesenchymal stem cells by human peripheral blood lymphocytes: A dual-mechanism for targeting senescent cell clearance and promoting cell proliferation in a coculture system [RNA-Seq PBL]

ABSTRACT: Rejuvenation of mesenchymal stem cells by human peripheral blood lymphocytes: A dual-mechanism for targeting senescent cell clearance and promoting cell proliferation in a coculture system [RNA-Seq PBL]

PROVIDER: PRJNA1314089 | ENA |

REPOSITORIES: ENA

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Rejuvenation of mesenchymal stem cells by human peripheral blood lymphocytes

Project description:Here we presented a novel approach to combat cellular senescence and promote cell proliferation by coculturing human MSCs with human peripheral blood lymphocytes (PBLs). In a heterogeneous population of MSCs comprising both aged and nonaged cells, PBL effector cells, rather than their cytokines, exhibited a dual role. They selectively induced apoptosis in aged cells by facilitating p53 SUMOylation and activating the p53-dependent mitochondrial pathway, while simultaneously safeguarding younger cells against senescence and promoting cell proliferation by activating Serpinb2/NF-κB signaling. This resulted in a decrease in aged MSCs and an enrichment of rejuvenated MSCs. This process effectively reversed the senescence phenotype, leading to the remodeling of stemness characteristics and the enhancement of functionality within the MSC population. Furthermore, MSCs rejuvenated by PBLs presented an enhanced therapeutic efficacy and a favorable safety profile.

2025-09-02 | GSE307003 | GEO

Regulation of mRNA transcript expression by hypoxia in human peripheral blood lymphocytes

Project description:The aim of the study is to evaluate oxygen regulated gene expression in human peripheral blood lymphocytes using microarray analysis. The results of this study are expected to provide useful marker transcripts whose expression is highly affected by hypoxia for further hypoxic gene expression studies using peripheral blood lymphocytes. Keywords: peripheral blood lymphocytes, hypoxia-regulated transcripts

2007-05-18 | GSE7833 | GEO

Differential gene expression of peripheral blood NKp65+ and NKp65- lymphocytes

Project description:We report differential gene expression in human peripheral blood NK cell enriched cytokine activated NKp65+ vs NKp65- innate lymphocytes.

2021-07-01 | GSE133772 | GEO

Rejuvenation of mesenchymal stem cells by human peripheral blood lymphocytes-A dual-mechanism for targeting senescent cell clearance and promoting cell proliferation in a coculture system

| PXD066147 |

Mapping of disease-associated expression polymorphisms in primary peripheral blood CD4+ lymphocytes

Project description:Analysis of expression quantitative trait loci (eQTLs) using RNA derived from freshly harvested peripheral blood CD4+ lymphocytes from 200 asthmatics collected in clinical settings. RNA was obtained from peripheral blood CD4+ lymphocytes at four study centers. Peripheral blood (17 cc) was collected into BD Vacutainer CPT tubes (BD Diagnostics, Franklin Lakes, New Jersey) and placed on ice. Samples were centrifuged within 1 hour of collection for 20 minutes at 1700RCF, followed by mononuclear cell layer isolation and suspension in 10 ml of PBS. We isolated CD4+ lymphocytes using anti-CD4+ microbeads by column separation (Miltenyi Biotec, Auburn, CA) using 20 Âµl anti-CD4+ Micro beads per 106 total cells

2010-06-23 | E-GEOD-22324 | biostudies-arrayexpress

CD8+ T cells in peripheral blood lymphocytes and tumor-infiltrating lymphocytes of melanoma patients

Project description:CD8+ T cells in peripheral blood lymphocytes and tumor-infiltrating lymphocytes of melanoma patients

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Differential gene expression of peripheral blood NKp65+ and NKp65- lymphocytes

Project description:Differential gene expression of peripheral blood NKp65+ and NKp65- lymphocytes

| PRJNA552528 | ENA

Mapping of disease-associated expression polymorphisms in primary peripheral blood CD4+ lymphocytes

2010-06-14 | GSE22324 | GEO

Rejuvenation of mesenchymal stem cells by human peripheral blood lymphocytes: A dual-mechanism for targeting senescent cell clearance and promoting cell proliferation in a coculture system [RNA-Seq]

Project description:Rejuvenation of mesenchymal stem cells by human peripheral blood lymphocytes: A dual-mechanism for targeting senescent cell clearance and promoting cell proliferation in a coculture system [RNA-Seq]

| PRJNA1314099 | ENA

Peripheral blood lymphocytes with different levels of gH2AX foci and micronuclei

Project description:Transcriptional profiling of peripheral blood lymphocytes with different levels of gH2AX foci and micronuclei after 0 and 2 Gy of gamma-rays. The aim was to identify differentially expressed genes, associated with level of gH2AX and micronuclei.

2017-03-25 | GSE97000 | GEO

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