Project description:It is metabolites derived from evolved Skeletonema marinoi that are resistant to algicidal bacteria, Kordia algicide. According to unpublished data (publication is in process) from Azizah et al, 2025. Title: Adaptive Evolution of an oxylipin-based chemical defence in a bloom-forming diatom exposed to algicidal bacteria. Authors: Muhaiminatul Azizah1, Janine F. M. Otto1, Nico Ueberschaar2, Markus Werner3, Oliver Werz3, Georg Pohnert1
Project description:We investigated the impact of SMAD2 linker phosphorylation (pSMAD2L) on gene expression in A549 cells. Data has been published in the British Journal of Cancer under the title “SMAD2 linker phosphorylation influences overall survival, proliferation, TGFβ1-dependent gene expression, and pluripotency-related proteins in NSCLC”.
Project description:We investigated the impact of SMAD2 linker phosphorylation (pSMAD2L) on TGF-beta 1 signaling in A549 cells. Data has been published in the British Journal of Cancer under the title “SMAD2 linker phosphorylation influences overall survival, proliferation, TGFβ1-dependent gene expression, and pluripotency-related proteins in NSCLC”.
Project description:Whole genome expression profile comparing MGAS315 treated with XIP pheromone versus vehicle-treated cells Interpretations are described further in the manuscript to be submitted: authors Mashburn-Warren, Morrison, and Federle. Title: The Cryptic Competence Pathway in Streptococcus pyogenes is Controlled by a Peptide Pheromone.
Project description:This series examines gene expression in the anterior midgut at several time points (2, 4, 8, & 16 h for males, 8 h for females) after topical application of juvenile hormone III (JHIII) or acetone (control) to adult beetles. In addition, gene expression in male anterior midguts were examined 24 h after phloem feeding or in unfed beetles. Keywords: North American pine engraver beetle; anterior midgut; juvenile hormone; pheromone biosynthesis; Coleoptera; Scolytidae Publication reference: Reference Type: Book Section Authors: Tittiger, Claus; Keeling, Christopher I.; Blomquist, Gary J. Year: 2005 Title: Some insights into the remarkable metabolism of the bark beetle midgut. Editor: Romeo, J.T. Book Title: Chemical ecology and phytochemistry of forest ecosystems City: Toronto Publisher: Elsevier Volume: 39 Pages: 57-78 Series Title: Recent Advances in Phytochemistry Keywords: other
Project description:Journal : Blood. 2009 Jul 9;114(2):469-77. Epub 2009 May 13. Title : Endothelial deletion of hypoxia-inducible factor-2alpha (HIF-2alpha) alters vascular function and tumor angiogenesis. Authors : Skuli N, Liu L, Runge A, Wang T, Yuan L, Patel S, Iruela-Arispe L, Simon MC, Keith B. Abstract : Hypoxia-inducible factor-2alpha (HIF-2alpha) is highly expressed in embryonic vascular endothelial cells (ECs) and activates the expression of target genes whose products modulate vascular function and angiogenesis. In this report, we describe a genetic model designed to test the physiologic consequences of deleting HIF-2alpha in murine endothelial cells. Surprisingly, mice with HIF-2alpha-deficient ECs developed normally but displayed a variety of phenotypes, including increased vessel permeability, aberrant endothelial cell ultrastructure, and pulmonary hypertension. Moreover, these animals exhibited defective tumor angiogenesis associated with increased hypoxic stress and tumor cell apoptosis. Immortalized HIF-2alpha-deficient ECs displayed decreased adhesion to extracellular matrix proteins and expressed reduced levels of transcripts encoding fibronectin, integrins, endothelin B receptor, angiopoietin 2, and delta-like ligand 4 (Dll4). Together, these data identify unique cell-autonomous functions for HIF-2alpha in vascular endothelial cells. Keywords: Murine lung endothelial cell study