Project description:Transcription profiling of mouse embryonic stem cell line CGR8 treated with Leukemia Inhibitory Factor (LIF) to identify LIF-dependent genes and early differentiation markers

2015-11-02 | E-TABM-667 | ExpressionAtlas

Proteomic characterization of CD34+ CD123+ stem cells from patients with acute myeloid leukemia

Project description:The comparative characterization of hematopoietic stem cells from healthy stem cell donors and patients with acute myeloid leukemia on a proteome level has the potential to reveal differentially regulated proteins which might be candidates for specific immunotherapy target molecules. Exemplarily, we analyzed the proteome of the cytosolic and the membrane fraction of CD34 and CD123 co-expressing FACS-sorted leukemic progenitors from five patients with acute myeloid leukemia employing mass spectrometry. As a reference, CD34+CD123+ normal hematopoietic progenitor cells from five healthy stem cell donors were analyzed. In this TMT 10-plex labeling based approach 2068 proteins were identified with 256 proteins differentially regulated in one or both cellular compartments. This study demonstrates the feasibility of a mass spectrometry based proteomic approach to detect differentially expressed proteins in two compartment fractions of leukemic stem cells as compared to their healthy stem cell counterparts.

2018-02-19 | PXD008378 | Pride

Jiao2018 - Feedback regulation in a stem cell model with acute myeloid leukaemia

Project description:This is a mathematical model describing the hematopoietic lineages with leukemia lineages, as controlled by end-product negative feedback inhibition. Variables include hematopoietic stem cells, progenitor cells, terminally differentiated HSCs, leukemia stem cells, and terminally differentiated leukemia stem cells.

2024-09-02 | BIOMD0000000898 | BioModels

E-MTAB-6738

Project description:RNA-seq in GR18 cell line to identify genes regulated by the Glucocorticoid Receptor

2025-01-23 | E-MTAB-6738 | ExpressionAtlas

E-GEOD-48339

Project description:Identification of candidate FOXA2-regulated genes in the adult mouse uterus

2015-07-20 | E-GEOD-48339 | ExpressionAtlas

E-GEOD-55014

Project description:Identification of candidate genes regulated by E4bp4 in murine bone marrow

2015-08-04 | E-GEOD-55014 | ExpressionAtlas

E-MTAB-7745

Project description:RNA-seq in GR18 cell line to identify genes regulated by the Glucocorticoid Receptor (24h treatment)

2025-01-23 | E-MTAB-7745 | ExpressionAtlas

E-TABM-670

Project description:Transcription profiling of mouse embryonic stem cell line CGR8 grown in presence of Leukemia Inhibitory Factor and treated with trichostatin A

2014-10-10 | E-TABM-670 | ExpressionAtlas

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