Homo sapiens
Ontology highlight
ABSTRACT:
PROVIDER: PRJNA144043 | ENA |
REPOSITORIES: ENA
Similar Datasets
Project description:Circulating RNAs profile in non-small cell lung cancer patients
| PRJNA286291 | ENA
Project description:East-Asian (EA) patients with Non Small Cell Lung Cancer (NSCLC) are associated with a high proportion of non-smoking women, EGFR activating somatic mutations, and clinical responses to tyrosine kinase inhibitors. We identify copy number alterations specific to EA and Western European (WE) NSCLCs and conducted an integrative analysis using transcritomic data for identifying copy-number-driven candidate genes. Samples were hybridized to Affymetrix Genome-Wide Human SNP 6.0 arrays according to the manufacturer’s specifications in the same center. 226 lung adenocarcinomas (90 East-Asian and 136 Western-European) were analyzed for copy-number aberrations (CNAs) using a common high resolution SNP microarray platform.
2011-11-22 | E-GEOD-33848 | biostudies-arrayexpress
Project description:Lung cancer remains a significant global health challenge, particularly in marginalized areas where access to early diagnostic tools is limited. The present study examined the potential of salivary proteomics as a non-invasive, cost-effective method for early lung cancer detection. Saliva samples were collected from 15 lung cancer patients and 15 matched healthy controls from the East Khasi Hills district of Meghalaya, India. Using liquid chromatography–tandem mass spectrometry (LC-MS/MS), a total of 2,784 proteins were identified, with 290 showing statistically significant differences in expression between the cancer and control groups. Among these, seven proteins (TUBB3, PTBP3, ESYT1, Rab27B, RUVBL1, Pyruvate Carboxylase, and CDK5RAP2) were uniquely expressed in cancer samples, suggesting their potential as specific biomarkers. Several proteins, including Kallikrein-7 (KLK7), Bleomycin Hydrolase (BLMH), HMGN5, GLUD1, and GLUL, were significantly upregulated in the saliva of lung cancer patients, indicating their role in tumor growth, chemoresistance and altered metabolism. Statistical analyses such as heatmap clustering, PCA, and volcano plots, confirmed distinct proteomic signatures between the cancer and control groups. These findings support the potential of salivary proteomics as a cost-effective and non-invasive tool for early lung cancer detection.
2025-11-03 | PXD064138 | Pride
Project description:Transcriptomic Analysis of Non-small Cell Lung Cancer Stem Cells
| PRJNA218111 | ENA
Project description:Integrative genome-wide analysis in non-small cell lung cancer cells
| PRJNA267557 | ENA
Project description:Contemporary Jews comprise an aggregate of ethno-religious communities whose worldwide members identify with each other through various shared religious, historical, and cultural traditions1,2. Historical evidence suggests common origins in the Middle East, followed by migrations leading to the establishment of communities of Jews in Europe, Africa, and Asia - in what is termed the Jewish Diaspora3-5. This complex demographic history imposes special challenges in attempting to address the genetic structure of the Jewish people6. While many genetic studies have shed light on Jewish diseases and origins, including those focusing on uniparentally- and biparentally-inherited markers7-16, genome-wide patterns of variation across the vast geographic span of Jewish Diaspora communities and their respective neighbors have yet to be addressed. Here we use high-density bead arrays to genotype individuals from 14 Jewish Diaspora communities, and compare these patterns of genome-wide diversity with those from 69 Old World non-Jewish populations, of which 25 have not been previously reported. These samples were carefully chosen to provide comprehensive comparisons between Jewish and non-Jewish populations in the Diaspora, as well as with non-Jewish populations from the Middle East and North Africa. Principal component and structure-like analyses identify previously unrecognized genetic substructure within the Middle East. Most Jewish samples form a remarkably tight sub-cluster that overlies Druze and Cypriot samples, but not samples from other Levantine populations or paired Diaspora host populations. In contrast, Ethiopian Jews (Beta Israel) and Bene Israel Indian Jews cluster with neighbouring autochthonous populations in Ethiopia and western India, respectively; despite a clear paternal link between the Bene Israel and the Levant. These results cast light on the variegated genetic architecture of the Middle East, and trace the origins of most Jewish Diaspora communities to the Levant. 466 samples are analysed on three different Illumina platforms.
2010-06-10 | E-GEOD-21478 | biostudies-arrayexpress
Project description:East-Asian (EA) patients with Non Small Cell Lung Cancer (NSCLC) are associated with a high proportion of non-smoking women, EGFR activating somatic mutations, and clinical responses to tyrosine kinase inhibitors. We identify copy number alterations specific to EA and Western European (WE) NSCLCs and conducted an integrative analysis using transcritomic data for identifying copy-number-driven candidate genes. Samples were hybridized to Affymetrix Genome-Wide Human SNP 6.0 arrays according to the manufacturer’s specifications in the same center.
2011-11-22 | GSE33848 | GEO
Project description:Whole-genome DNA methylation profiling of oral cancer in patients from North-Eastern states of India. The Illumina Infinium 450k Human DNA methylation BeadChip was used to screen the entire DNA methylation profiles across approximately 485,577 CpGs in matched oral cancer samples. Samples included 12 paired samples (12 cancer and 12 normal).
2019-04-09 | GSE97784 | GEO