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Ixodes scapularis

ABSTRACT: the black-legged tick Ixodes scapularis is the vector for the Lyme disease spirochete Borrelia burgdorferi

PROVIDER: PRJNA16233 | ENA |

REPOSITORIES: ENA

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			Action	DRS
		Other
	SRR1188750_1.fastq.gz	Fastqsanger.gz
	SRR1188750_2.fastq.gz	Fastqsanger.gz
	SRR1189460_1.fastq.gz	Fastqsanger.gz
	SRR1189460_2.fastq.gz	Fastqsanger.gz

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Peromyscus leucopus, Mus musculus, and humans have distinct transcriptomic responses to larval Ixodes scapularis bites.

Project description:Ixodes scapularis are an important vector for at least six tick-borne human pathogens, including the predominant North American Lyme disease spirochete Borrelia burgdorferi. The ability for these ticks to survive in nature is credited, in part, to their ability to feed on a variety of hosts without excessive activation of the vertebrate immune system. While the ability for nymphal ticks to feed on a variety of hosts has been well-documented, the host-parasite interactions between larval I. scapularis and different vertebrate hosts is relatively unexplored. Here we report on the changes in the vertebrate transcriptome present at the larval tick bite site using the natural I. scapularis host Peromyscus leucopus, a non-natural rodent host Mus musculus (BALB/c), and humans. We note substantially less evidence of inflammation in P. leucopus compared to BALB/c mice and pronounced evidence of inflammation in humans. These data suggest that larval I. scapularis may have a reduced ability to suppress host immunity in non-natural hosts and expand our overall understanding of I. scapularis feeding.

2025-02-20 | GSE266088 | GEO

The transcriptome of Ixodes scapularis salivary glands at single cell resolution

Project description:Applications of transcriptomics have significantly advanced the identification of numerous tick salivary molecules involved in feeding and the transmission of tick-borne pathogens. In this study, we analyze the salivary gland transcriptome of Ixodes scapularis, the main vector of Borrelia burgdorferi in the U.S., at single cell resolution.

2026-02-19 | GSE289983 | GEO

RNA-seq of Ixodes scapularis salivary glands [bulkRNA-dissociated-SG]

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RNA-seq of Ixodes scapularis salivary glands [bulkRNA-intact-SG]

2026-02-20 | GSE290647 | GEO

Tick Adiponectin Receptor-Mediated Phospholipid Metabolism Contributes to Borrelia burgdorferi Colonization

Project description:Adiponectin-mediated pathways contribute to mammalian homeostasis; however, little is known about adiponectin and adiponectin receptor signaling in arthropods. In this study, we demonstrate that Ixodes scapularis ticks have an adiponectin receptor-like protein (ISARL) but lack adiponectin, suggesting activation by alternative pathways. ISARL expression is significantly upregulated in the tick gut after Borrelia burgdorferi infection, suggesting that ISARL signaling may be co-opted by the Lyme disease agent. Consistent with this, RNA interference (RNAi)-mediated silencing of ISARL significantly reduced the B. burgdorferi burden in the tick. RNA-seq-based transcriptomics and RNAi assays demonstrate that ISARL-mediated phospholipid metabolism by phosphatidylserine synthase I is associated with B. burgdorferi survival. Furthermore, the tick complement C1q-like protein 3 interacts with ISARL, and B. burgdorferi facilitates this process. This study identifies a new tick metabolic pathway that is connected to the life cycle of the Lyme disease spirochete.

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mRNA vaccination induces tick resistance and prevents transmission of the Lyme Disease agent

Project description:An Ixodes scapularis saliva mRNA vaccine induces tick resistance and prevents Borrelia burgdorferi infection in guinea pigs

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Borrelia burgdorferi infected Ixodes scapularis nymph saliva proteome

Project description:Lyme disease (LD) is one of the most important human vector-borne diseases in North America. Since transmission of Borrelia burgdorferi (Bb), the causative agent of LD, is influenced by yet unknown tick saliva proteins (TSP), the discovery and characterization of such TSPs are highly sought after for their potential as tick-antigen based vaccine targets. We validated a novel non-invasive approach of collecting sufficient amounts of saliva from unfed, partially fed (12, 24, 36, 48, 60, and 72h), and replete fed Ixodes scapularis nymphs for identification of tick saliva proteins using the LC-MS/MS approach. Our data has described TSPs that might be injected into the host within few hours of the tick starting to feed and are likely associated with manipulating host immunity to facilitate transmitted Bb to colonize the host. Thus, these data will serve as a source for Bb-infection associated TSPs that might be targeted in tick-antigen based vaccines to prevent LD. Equally important, the non-invasive method to collect nymph tick saliva is likely to provide transformative impact on research to understand transmission of other TBD agents.

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Ixodes scapularis

Project description:Ixodes scapularis midgut Transcriptome following SelK knockdown in Borrelia burgdorferi-infected ticks

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Dual roles for a tick protein disulfide isomerase during the life cycle of the Lyme disease agent [I. scapularis]

Project description:To determine whether the influences of Ixodes scapularis protein disulfide isomerase A6 (IsPDIA6) on Borrelia burgdorferi colonization is the result of physiological responses, we performed RNA-sequencing (RNA-seq) to compare the transcriptomes of control (GFP) and IsPDIA6-silenced ticks.

2024-10-14 | GSE273568 | GEO

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