Vibrio ordalii FS-238
Ontology highlight
ABSTRACT:
PROVIDER: PRJNA164837 | ENA |
REPOSITORIES: ENA
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Project description:Vibrio ordalii is the causative agent of atypical vibriosis in salmonids cultured in Chile. While extensive research has provided valuable insights into V. ordalii through phenotypic, antigenic, and genetic typing, as well as various virulence mechanisms (e.g., capsular material, iron-uptake systems, and outer membrane vesicles [OMVs]), proteomic characterization remains largely unexplored. This study aimed to advance the proteomic knowledge of Chilean V. ordalii Vo-LM-18 and its OMVs, which have been extensively characterized in several studies and have demonstrated their virulence. Using Nano-UHPLC-LC-MS/MS, we identified 2,242 proteins in the bacterium and 1,755 proteins in its OMVs. Among these, 644 unique proteins were detected in V. ordalii Vo-LM-18, 156 unique proteins were found in its OMVs, and 1,596 proteins were shared between both components. bioinformatics compartment prediction (PSORT algorithm) revealed that the major categories in the OMVs were similar to those in the bacteria (i.e., cytoplasmic and cytoplasmic membrane proteins), though with different proportions. Functional annotation with Gene Ontology identified 37 biological pathways in V. ordalii Vo-LM-18 and 28 in its OMVs. Proteins associated with transport, transcription, and virulence were predominant in both the bacteria and the vesicles. Comparison between the strain Vo-LM-18 and its OMVs showed evident differences in protein expression, with OMVs expressing a higher number of virulence-associated proteins, including those related to iron- and heme-uptake mechanisms. Notable pathways in the bacteria included flagellum assembly, heme group-associated proteins, and protein biosynthesis. This proteomic analysis also represents the first detection of RTX toxin in a V. ordalii strain (Vo-LM-18) and its vesicles. Our results highlight the crucial role of OMVs in the pathogenesis and adaptation of V. ordalii, suggesting their potential as diagnostic biomarkers and therapeutic targets for bacterial infections.
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