Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Mycobacterium tuberculosis variant bovis BCG str. Moreau RDJ

ABSTRACT: Brazilian vaccine strain

PROVIDER: PRJNA18279 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Similar Datasets

Cultivation impact on the protein expression profile of Mycobacterium bovis BCG strains Moreau and Pasteur

Project description:The BCG vaccine (Bacille Calmette-Guerin), only prophylactic measure against tuberculosis (TB), was obtained in the early twentieth century by Calmette and Guérin after 231 passages of a M. bovis clinical isolate in medium containing glycerin and bovine bile. Its protective efficacy against pulmonary TB in adults varies from 0-80% and the genetic differences among vaccines strains used worldwide contribute to this variation. The Brazilian vaccine strain, BCG Moreau, is considered a primitive strain and more immunogenic, closer to the original BCG when compared to newer strains, such as BCG Pasteur (reference strain). The characterization of BCG sub-strains can contribute not only to a better understanding of the vaccine and its protective effect, but also, in elucidating how different BCG culture conditions may contribute to the impact on the host's immune response. Thus, we aimed to characterize the differences in gene expression through the intracellular proteomic profile of BCG Moreau and Pasteur strains, cultivated in Sauton or 7H9 medium, using the methodology of two-dimensional electrophoresis (2DE) and mass spectrometry.

2025-10-23 | PXD030179 | Pride

Mycobacterium tuberculosis variant bovis BCG

Project description:Complete genome sequencing and assembly of Mycobacterium tuberculosis variant bovis strain BCG SL 222 Sofia (descending from Russian BCG-I strain)

| PRJNA673391 | ENA

Mycobacterium tuberculosis variant bovis BCG

Project description:Gene Expression profiling of M. bovis BCG strain under hypoxia

| PRJNA105573 | ENA

Mycobacterium tuberculosis variant bovis BCG

Project description:Gene expression profiling of M tuberculosis BCG strain during extended stationary and resuscitation phase of growth

| PRJNA116655 | ENA

Mycobacterium tuberculosis variant bovis BCG str. Tokyo 172

Project description:This strain is being sequenced for comparative genome analysis

| PRJDA31211 | ENA

Mycobacterium tuberculosis variant bovis BCG str. Tokyo 172

Project description:A thyX deletion mutant strain of Mycobacterium bovis BCG Tokyo 172

| PRJDB11898 | ENA

Exploring the potential role of moonlighting function of the surface-associated proteins from Mycobacterium bovis BCG Moreau and Pasteur by comparative proteomic

Project description:Tuberculosis (TB) is one of major causes of death worldwide. Bacillus Calmette-Guerin (BCG) is the only licensed TB vaccine and its inability to protect against adult pulmonary TB can be due to genetic differences among strains described since the 1940s. In this work, we compared the proteomic profile of the surface-associated proteins from M. bovis BCG Moreau, the Brazilian vaccine strain, and the BCG Pasteur reference strain. The methodology used was 2D-gel electrophoresis combined with mass spectrometry techniques (MALDI-TOF/TOF). We identified 115 proteins. Of these, 24 proteins showed differential expression between the two BCG strains. Furthermore, 27 proteins previously described as displaying moonlighting function were identified, 8 of these proteins showed variation in abundance comparing BCG Moreau to Pasteur and 2 of them presented two different domain hits.

2019-05-15 | PXD006141 | Pride

Mycobacterium tuberculosis variant bovis BCG str. China

Project description:Mycobacterium bovis BCG str. China genome sequencing project.

| PRJNA63833 | ENA

Mycobacterium tuberculosis variant bovis BCG str. Mexico

Project description:Mycobacterium bovis BCG str. Mexico genome sequencing project

| PRJNA45811 | ENA

Mycobacterium tuberculosis variant bovis BCG str. Frappier

Project description:Mycobacterium tuberculosis variant bovis BCG str. Frappier Genome sequencing and assembly

| PRJNA167545 | ENA