Project description:The current study is aimed at elucidating the proteomic responses in durum wheat Triticum aestivum L triggered by native PGPB, CP_4 (Bacillus subtilis) alone and in combination with AM fungi Glomus fasciculatum under field conditions Our results suggest that native PGPB B subtilis ( in combination with AM fungi Glomus fasciculatum (B+ may promote differential abundance of multiple regulatory seed storage proteins over untreated control Thus, combined application of native PGPB and AMF could offer a more sustainable approach to enhance crop yield.
Project description:In this study we assed protein variation in the liver and brain tissue of hake among three sampling populations by using 2D/DIGE and mass spectrometry techniques"
Project description:The carotid body (CB) is a major arterial chemoreceptor containing glomus cells whose activities are regulated by changes in arterial blood contents including oxygen. We employed the single cell RNASeq method by performing next-generation sequencing on single glomus cellderived cDNAs to eliminate contamination of genes derived from other cell types present in the CB. This study has generated a CB expression profile containing novel glomus cell specific genes. The wealth of information provided through this study offers a valuable foundation for identifying molecules functioning in the CB.
Project description:The carotid body is a peripheral chemoreceptor organ containing a neurogenic niche with stem cells and immature neuronal cells that convert into new neurons (glomus cells) upon activation by hypoxia. We have used microarray to compare the gene expression programs of glomus cells and neuroblasts, both in normoxic and hypoxic (3 days) conditions, to highlight the molecular mechanisms underlying fast neurogenesis
Project description:Papillon-Lefèvre Syndrome (PLS) is an autosomal recessive monogenic disease caused by loss-of-function mutations in the CTSC gene. In this study we performed whole genome sequencing on two siblings, with the PLS-typical symptoms. After sequencing the CTSC gene was analyzed to confirm the PLS diagnosis genetically.