Project description:Inflammatory crosstalk between perivascular adipose tissue and and blood vessel wall may contribute to atherosclerosis pathogenesis, and exhibits more pro-inflammatory than adipogenic phenotype than subcutaneous adipocytes. To identify a genomic basis for biologic differences, we performed genome-wide expression to identiy expression genes differentially regulated between perivascular and subcutaneous adipocytes.for biologic differences. We performed global gene expression analyses on in vitro differentiated adipocytes from human left coronary artery perivascular adipose tissue and subcutaneous adipose tissues derived from unrelated donors who were non-obese and did not have any known metabolic or atherosclerotic disease.
Project description:This SuperSeries is composed of the following subset Series: GSE20680: Whole Blood Cell Gene Expression Profiling in Patients with Coronary Artery Disease from the Cathgen Registry GSE20681: Whole Blood Cell Gene Expression Profiling in Patients with Coronary Artery Disease from the PREDICT Trial Refer to individual Series
Project description:Perivascular adipose (PVAT and subcutaneous adipose tissue (SubQ) from donors undergoing mitral valve repair/replacement (VR) and coronary artery bypass graft (CABG) surgeries were analyzed. There are 3 SWATH data sets. The first contains CABP PVAT, CABG SubQ, VR PVAT, and VR SubQ. The second includes only CABG PVAT from donors with and without diabetes. The third set includes CABG PVAT and SubQ and VR PVAT. Additionally, there are multiple reaction monitoring data sets comparing CABG PVAT with and without diabetes, CABG SubQ with and without diabetes, CABG PVAT to CABG SubQ both without diabetes, CABG PVAT to CABG SubQ both with diabetes, and CABG PVAT without diabetes to VR PVAT without diabetes.
Project description:Inflammatory crosstalk between perivascular adipose tissue and and blood vessel wall may contribute to atherosclerosis pathogenesis, and exhibits more pro-inflammatory than adipogenic phenotype than subcutaneous adipocytes. To identify a genomic basis for biologic differences, we performed genome-wide expression to identiy expression genes differentially regulated between perivascular and subcutaneous adipocytes.for biologic differences.
