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Mus musculus

ABSTRACT: Gene expression analysis of murine peritoneal macrophages deficient for SAMHD1 and IFNAR

PROVIDER: PRJNA193592 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR789154.fastq.gz	Fastqsanger.gz
	SRR789155.fastq.gz	Fastqsanger.gz
	SRR789156.fastq.gz	Fastqsanger.gz
	SRR789157.fastq.gz	Fastqsanger.gz
	SRR789158.fastq.gz	Fastqsanger.gz

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Gene expression analysis of murine peritoneal macrophages deficient for SAMHD1 and IFNAR

Project description:To investigate the contribution of type-1 IFN signalling to the upregulation of IFN- stimulated genes in SAMHD1-deficient cells, we performed global gene expression analysis of SAMHD1-deficient IFNAR-/- macrophages. Peritoneal macrophages from ten SAMHD1-deficient IFNAR-/- and six SAMHD1-deficient controls were FACS sorted. RNA was subjected to next generation mRNA sequencing.

2013-07-01 | E-GEOD-45358 | biostudies-arrayexpress

Mus musculus

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Project description:Gene expression analysis of murine SAMHD1 deficient peritoneal macrophages (S1056 to S1075)

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Gene expression analysis of murine peritoneal macrophages deficient for SAMHD1 and IFNAR

2013-07-01 | GSE45358 | GEO

Gene expression analysis of murine SAMHD1 deficient peritoneal macrophages (S1056 to S1075)

Project description:To elucidate responses of myeloid cells to SAMHD1 deficiency in the absence of exogenous viral infection, we performed global gene expression analysis of SAMHD1 deficient macrophages. Peritoneal macrophages from 10 mutants and 10 controls were FACS sorted. Isolated RNA was subjected to next generation mRNA sequencing.

2013-03-31 | E-GEOD-41879 | biostudies-arrayexpress

Gene expression analysis of murine SAMHD1 deficient peritoneal macrophages

Project description:To elucidate responses of myeloid cells to SAMHD1 deficiency in the absence of exogenous viral infection, we performed global gene expression analysis of SAMHD1 deficient macrophages. Peritoneal macrophages from nine mutants and nine controls were FACS sorted. Cells from three animals were pooled to yield three poolls per group. RNA from these pools was subjected to next generation mRNA sequencing

2012-12-01 | E-GEOD-37236 | biostudies-arrayexpress

Gene expression analysis of murine SAMHD1 deficient peritoneal macrophages

2012-12-01 | GSE37236 | GEO

Gene expression analysis of murine SAMHD1 deficient peritoneal macrophages (S1056 to S1075)

2013-03-31 | GSE41879 | GEO

Mus musculus

Project description:GATA6 dependent gene regulation in peritoneal macrophages

| PRJNA244314 | ENA

Bidirectional Introgression between Mus musculus domesticus and Mus spretus.

Project description:Introgressed variants from other species can be an important source of genetic variation because they may arise rapidly, can include multiple mutations on a single haplotype, and have often been pretested by selection in the species of origin. Although introgressed alleles are generally deleterious, several studies have reported introgression as the source of adaptive alleles-including the rodenticide-resistant variant of Vkorc1 that introgressed from Mus spretus into European populations of Mus musculus domesticus. Here, we conducted bidirectional genome scans to characterize introgressed regions into one wild population of M. spretus from Spain and three wild populations of M. m. domesticus from France, Germany, and Iran. Despite the fact that these species show considerable intrinsic postzygotic reproductive isolation, introgression was observed in all individuals, including in the M. musculus reference genome (GRCm38). Mus spretus individuals had a greater proportion of introgression compared with M. m. domesticus, and within M. m. domesticus, the proportion of introgression decreased with geographic distance from the area of sympatry. Introgression was observed on all autosomes for both species, but not on the X-chromosome in M. m. domesticus, consistent with known X-linked hybrid sterility and inviability genes that have been mapped to the M. spretus X-chromosome. Tract lengths were generally short with a few outliers of up to 2.7 Mb. Interestingly, the longest introgressed tracts were in olfactory receptor regions, and introgressed tracts were significantly enriched for olfactory receptor genes in both species, suggesting that introgression may be a source of functional novelty even between species with high barriers to gene flow.

| S-EPMC8784167 | biostudies-literature

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