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Mus musculus

ABSTRACT: Transcriptional Profiling of Neuronal APP/APLP2 Double-Conditional Knockout Mice.

OTHER RELATED OMICS DATASETS IN: E-GEOD-48622

PROVIDER: PRJNA210871 | ENA |

REPOSITORIES: ENA

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E-GEOD-48622

Project description:Transcriptional Profiling of Neuronal APP/APLP2 Double-Conditional Knockout Mice.

2015-07-16 | E-GEOD-48622 | ExpressionAtlas

Transcriptional Profiling of Neuronal APP/APLP2 Double-Conditional Knockout Mice.

Project description:Gene expression analysis of 2-month-old APP/APLP2 double-conditional Knockout (N-dCKO) mice and littermate APLP2 knockout controls, APP knockout and wildtype controls.

2013-07-10 | GSE48622 | GEO

Transcriptional Profiling of Neuronal APP/APLP2 Double-Conditional Knockout Mice.

Project description:Gene expression analysis of 2-month-old APP/APLP2 double-conditional Knockout (N-dCKO) mice and littermate APLP2 knockout controls, APP knockout and wildtype controls. Mouse hippocampus were dissected for RNA extraction and hybridization on Affymetrix microarrays.

2013-07-10 | E-GEOD-48622 | biostudies-arrayexpress

Mus musculus

Project description:Gene expression analysis of double conditional knockout mice for Sbno1 and Trp53

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Loss of BAP1 cooperates with TP53 deficiency to transform a common myelo-erythroid progenitor (ChIP-seq - mus musculus)

Project description:We performed RNA-seq and ChIP-seq in lineage depleted bone marrow cells isolated from single and double Bap1 and Trp53 knockout mice to identify transcriptional and epigenetic programs that drive erythroleukemia.

2026-03-05 | GSE173547 | GEO

Mus musculus

Project description:Pre-T cells from control and Zfp36l1, Zfp36l2 double conditional knockout mice. [iCLIP]

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Mus musculus

Project description:RNAseq of pre-T cells from control and Zfp36l1, Zfp36l2 double conditional knockout mice.

| PRJNA315110 | ENA

Loss of BAP1 cooperates with TP53 deficiency to transform a common myelo-erythroid progenitor (scRNA-seq - mus musculus)

Project description:We performed scRNA in sorted LinnegcKit+ bone marrow cells from single and double Bap1 and Trp53 knockout mice to identify transcirptional programs driving erythroleukemia.

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Mus musculus

Project description:Expression profiling of dendritic cell (DC) progenitors from Gata2 conditional knockout mice

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Testis expression in Mus musculus domesticus WSB/EiJ x Mus musculus musculus PWD/PhJ F2 hybrids

Project description:To characterize the genetic basis of hybrid male sterility in detail, we used a systems genetics approach, integrating mapping of gene expression traits with sterility phenotypes and QTL. We measured genome-wide testis expression in 305 male F2s from a cross between wild-derived inbred strains of M. musculus musculus and M. m. domesticus. We identified several thousand cis- and trans-acting QTL contributing to expression variation (eQTL). Many trans eQTL cluster into eleven ‘hotspots,’ seven of which co-localize with QTL for sterility phenotypes identified in the cross. The number and clustering of trans eQTL - but not cis eQTL - were substantially lower when mapping was restricted to a ‘fertile’ subset of mice, providing evidence that trans eQTL hotspots are related to sterility. Functional annotation of transcripts with eQTL provides insights into the biological processes disrupted by sterility loci and guides prioritization of candidate genes. Using a conditional mapping approach, we identified eQTL dependent on interactions between loci, revealing a complex system of epistasis. Our results illuminate established patterns, including the role of the X chromosome in hybrid sterility.

2014-05-01 | GSE54089 | GEO

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