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Homo sapiens

ABSTRACT: CIITA regulated genes in human B cells

PROVIDER: PRJNA230503 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR1787810.fastq.gz	Fastqsanger.gz
	SRR1787811.fastq.gz	Fastqsanger.gz
	SRR1787802.fastq.gz	Fastqsanger.gz
	SRR1787812.fastq.gz	Fastqsanger.gz
	SRR1787803.fastq.gz	Fastqsanger.gz

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Project description:The MHC class II transactivator (CIITA) is essential for the expression of MHC-II genes. CIITA functions as a transcriptional activator when bound to genes although repressive roles have been reported at some loci in other cell types. To define the role of CIITA in gene regulation in human B cells, we performed ChIP-seq for CIITA using three independent antibodies, the histone marks H3K4me3 and H3K27ac, and ATAC-seq in the Raji human B cell line. Additionally, we profiled H3K27ac and ATAC-seq in the CIITA-null RJ2.2.5 cell line. A core set of CIITA peaks were identified that overlapped in all antibodies. Using the H3K27ac, H3K4me3, and ATAC-seq profiles generated in CIITA+ Raji and CIITA-null RJ2.2.5 cells CIITA dependent chromatin modifications were identified. These data define the CIITA regulated genes in human B cells.

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