Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Danio rerio

ABSTRACT: Deficiency in glucose transporter 12 results in heart failure and a diabetic phenotype in zebrafish

PROVIDER: PRJNA255949 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR1523211.fastq.gz	Fastqsanger.gz
	SRR1523212.fastq.gz	Fastqsanger.gz
	SRR1523213.fastq.gz	Fastqsanger.gz
	SRR1523214.fastq.gz	Fastqsanger.gz
	SRR1523215.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 6

Similar Datasets

Proteomic Analysis insights into Potential Mechanism of SGLT2 Inhibitors cardiovascular benefit in Diabetic cardiomyopathy

Project description:Diabetic cardiomyopathy (DCM) is one of the major causes of heart failure in diabetic patients, but its pathogenesis remains unclear. Sodium glucose cotransporter 2 inhibitors (SGLT2i) can effectively reduce the risk of cardiovascular death and heart failure in DCM patients, but the underlying mechanism has not been elucidated. We established a DCM rat model followed by treatment with empagliflozin (EMPA) for 12 weeks. The proteomics of the myocardium in the rat model was performed to identify the potential targets and signaling pathways associated with the cardiovascular benefit of SGLT2i.

2023-03-10 | PXD036090 | Pride

Transcription profiling time series of Danio rerio heart regeneration

Project description:Amputation of heart tissue followed by regeneration of the heart. Samples were taken at 0 hpa (hours post-amputation), 6 hpa, 12 hpa, 24 hpa, 3 dpa and 5 dpa.

2008-09-05 | E-MEXP-1239 | biostudies-arrayexpress

Title Page Cardiac Gene Therapy Rescues Diabetic Cardiomyopathy and Lowers Blood Glucose

Project description:Diabetic cardiomyopathy, an increasingly global epidemic and a major cause of heart failure with preserved ejection fraction (HFpEF), is associated with hyperglycemia, insulin resistance, and intra-cardiomyocyte calcium mishandling. Here we identify that, in db/db mice with type 2 diabetes induced HFpEF, abnormal remodeling of cardiomyocyte transverse-tubule microdomains occurs with downregulation of the membrane scaffolding protein cardiac bridging integrator 1 (cBIN1). Transduction of cBIN1 by AAV9 gene therapy can restore transverse-tubule microdomains to normalize intracellular distribution of calcium handling proteins and, surprisingly, glucose transporter 4 (GLUT4). Cardiac proteomics revealed that AAV9-cBIN1 normalizes components of calcium handling and GLUT4 translocation machineries. Functional studies further identified that AAV9-cBIN1 normalizes insulin-dependent glucose uptake in diabetic cardiomyocytes. Phenotypically, AAV9-cBIN1 rescues cardiac lusitropy, improves exercise intolerance, and ameliorates hyperglycemia in diabetic mice. Restoration of transverse-tubule microdomains can improve cardiac function in the setting of diabetic cardiomyopathy, and also improve systemic glycemic control.

2023-10-24 | PXD044236 | Pride

Danio rerio

Project description:Assessment of hematopoietic failure due to RPL11 deficiency in a zebrafish model of Diamond–Blackfan anemia by deep sequencing

| PRJNA222400 | ENA

Danio rerio

Project description:Zebrafish heart regeneration

| PRJNA355135 | ENA

Danio rerio

Project description:Zebrafish heart regeneration

| PRJNA119275 | ENA

Danio rerio

Project description:Zebrafish heart regeneration

| PRJNA1058587 | ENA

Danio rerio

Project description:FOXN3 regulates hepatic glucose utilization

| PRJNA317597 | ENA

Enhanced Myocardial Glucose Delivery Accelerates Development of Mitochondrial Dysfunction in the Diabetic Heart

Project description:Cardiac glucose delivery and utilization are reduced in diabetes despite hyperglycemia. Mitochondrial dysfunction contributes to heart failure in diabetic patients. The loss of mitochondrial substrate flexibility in regulating cellular and cardiac function is actively under investigation.

2020-10-05 | GSE123975 | GEO

Danio rerio

Project description:Zebrafish Hypoxia study Heart array

| PRJNA95495 | ENA