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Homo sapiens

ABSTRACT: Small RNA Sequencing of Minor Salivary Glands of Sjögren's syndrome

PROVIDER: PRJNA261250 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR1577670.fastq.gz	Fastqsanger.gz
	SRR1577671.fastq.gz	Fastqsanger.gz
	SRR1577528.fastq.gz	Fastqsanger.gz

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scRNA-seq of human CD45+ cells proliferated in the salivary grand or peripheral blood of CD8T cells depleted PBMC-transferred humanized mice

Project description:We found that the transfer of PBMCs depleted of CD8 T cells into immunodeficient mice resulted in the development of Sjögren's syndrome-like salivary gland symptoms without causing GVHD. To characterize the human immune cells infiltrating the salivary glands, we examined the profiles of human immune cells in the salivary glands or peripheral blood of humanized mice by 10x Genomics single-cell RNA sequencing (scRNA-seq). We revealed that human Tph-like cells co-expressing IL-21 and CXCL13 were highly infiltrated in the salivary glands of CD8 T cell-depleted humanized mice.

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Project description:Genome wide DNA methylation profiling of human labial salivary gland (LSG) biopsy samples obtained from 28 female members of the Sjögren's International Collaborative Clinical Alliance (SICCA) Registry. The Illumina HumanMethylation450 BeadChip platform was used to obtain DNA methylation profiles across more than 450,000 highly informative CpG sites. Samples included 15 non-case glands, and 13 glands from patients with Sjögren's Syndrome.

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Homo sapiens

Project description:Microarray analysis of minor salivary glands from patients with primary Sjögren’s syndrome (SS) or non-SS

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Project description:The circumvallate papillae (CVP) and foliate papillae (FoP) of the posterior tongue contain taste buds in close proximity to specialized salivary glands, known as von Ebner and minor salivary glands, respectively. The developmental relationship between taste buds and these salivary glands remains largely unexplored. Lineage tracing studies in mice have revealed that Lgr5 marks taste bud stem cells. Here, we report single-cell RNA sequencing of the entire CVP and FoP of mice, yielding transcriptional profiles of cells from tongue surface epithelium, taste buds and the associated salivary glands. We unveiled a developmental trajectory in which taste buds, the associated salivary glands and the non-taste tongue surface epithelium originate from a common Lgr5+ cell. We describe long-term organoid culture conditions for these cells and confirm their tripotency at the clonal level in vitro. CVP and FoP harbor chemosensory units consisting of taste bud and salivary gland cells derived from the same parental Lgr5+ stem cell.

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Tripotent Lgr5 stem cells in the posterior tongue generate non-taste lingual, taste and salivary gland cells [Bulk RNA-seq]

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Project description:Analysis of targets organs might help to get new insights into the pathogenesis of autoimmune diseases. We used global gene expression profiling of minor salivary glands to identify distinct patterns of gene expression in patients with primary Sjögrens syndrome (pSS), a frequent and prototype systemic autoimmune disease. Gene expression signature allowed to distinguish most patients with pSS from healthy controls

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Gene expression in minor salivary gland of patients with Sjogren's syndrome (SS) and control

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